| Type | Description |
|---|---|
| Definition | phosphodiesterase 4B, cAMP specific |
| Date | Results | Publications |
|---|---|---|
| 2019-11-30 11:59:00 | these findings indicate that PDE4B plays an important role in the development of acute and chronic inflammatory response and consequent recovery following spinal cord injury | 30557659 |
| 2019-07-13 12:33:00 | In vivo, the atropine-dependent prolongation of heart rate increase was blunted in PDE4D but not in wildtype or PDE4B knockout mice. The authors propose that inhibition of PDE4 by atropine accounts, at least in part, for the induction of tachycardia and the arrhythmogenic potency of this drug. | 29123207 |
| 2019-01-19 10:48:00 | Study combined mutational analysis in the Apc mutated mice with published studies of frank colon cancer in patients to deduce that Pde4b has two strong biological functions. It negatively regulates colonic adenomagenesis in Apc mutated mice. In patients, PDE4B is most commonly inactivated by an epigenetic process. | 30188895 |
| 2018-12-01 12:02:00 | PDE4B-deficient mice displayed an increased circulating IL-1Ra, suggesting a protective role of PDE4B inactivation in vivo. | 28383060 |
| 2018-08-18 10:52:00 | PDE4B1-D564A transgenic mice demonstrate increased phosphorylation of CREB and ERK1/2, consistent with activation of ERK1/2 and potentially other kinases, increased hippocampal neurogenesis, and alterations in hippocampal slice electrophysiology consistent with augmentation of hippocampal long-term potentiation. Mice are more active but have no major changes in associative learning or other behavior. | 29197324 |
| Type | IDs |
|---|---|
| Synonymous | Dpde4, R74983, dunce |
| Gene |
UniProtKB-ID:
Q6IQY6_MOUSE,
Q80VK8_MOUSE,
B1AWD0_MOUSE,
B1AWC8_MOUSE,
Q3TTI9_MOUSE,
Q8VBU5_MOUSE,
B1AWC9_MOUSE
UniprotKB:
Q6IQY6,
Q80VK8,
B1AWD0,
B1AWC8,
Q3TTI9,
Q8VBU5,
B1AWC9
UniParc:
UPI0000022EF2,
UPI0000028729,
UPI000017D9FA,
UPI00005B1D2A,
UPI000059E00C,
UPI000059E00B,
UPI000037810C
EMBL:
AL772358,
AF326556,
AL732551,
AL807794,
AF326555,
BC049864,
AL772293,
AK161341,
BC071259
Ensembl:
ENSMUSG00000028525
KO:
mmu:18578
|
| Nucleutide sequences |
EMBL-CDS:
AAH71259.1,
AAH49864.1,
BAE36336.1,
AAL37401.1,
AAL37402.1
Ensembl_TRS:
ENSMUST00000097949,
ENSMUST00000106907,
ENSMUST00000097950,
ENSMUST00000106904,
ENSMUST00000030251,
ENSMUST00000106908,
ENSMUST00000106911
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000095561,
ENSMUSP00000102520,
ENSMUSP00000095562,
ENSMUSP00000102517,
ENSMUSP00000030251,
ENSMUSP00000102521,
ENSMUSP00000102524
RefSeq:
NP_062814.2,
XP_036019718.1,
XP_036019717.1,
XP_006502918.1,
NP_001171453.1,
XP_006502919.1,
NP_001171454.1,
XP_036019716.1,
NP_001171451.1,
NP_001361709.1,
NP_001171452.1
|
| Others |
UniRef100:
UniRef100_B1AWD0,
UniRef100_B1AWC9,
UniRef100_Q80VK8,
UniRef100_Q6IQY6,
UniRef100_Q8VBU5,
UniRef100_B1AWC8
UniRef90:
UniRef90_B1AWD0,
UniRef90_Q07343-4,
UniRef90_Q80VK8,
UniRef90_Q8VBU5,
UniRef90_Q07343
UniRef50:
UniRef50_Q80VK8,
UniRef50_Q08499-4,
UniRef50_Q07343,
UniRef50_Q07343-3
UniGene:
Mm.20181
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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