| Type | Description |
|---|---|
| Definition | phosphodiesterase 4A, cAMP specific |
| Date | Results | Publications |
|---|---|---|
| 2017-12-16 12:33:00 | In conclusion, our data demonstrated that UFM24 inhibits oxidative burst in human neutrophils through inhibition of PDE4 activity. UFM24 also exhibited significant protection against endotoxin-induced acute lung injury (ALI)in mice. UFM24 has potential as an anti-inflammatory agent for treating neutrophilic lung damage. | 28263828 |
| 2016-03-05 10:17:00 | PDE4 inhibition reduces neointima formation and inhibits VCAM-1 expression and histone methylation in an Epac-dependent manner. | 25640159 |
| 2015-03-07 12:20:00 | results suggest that PDE4A may be important in the regulation of emotional memory and anxiety-like behavior, but not emesis | 24563185 |
| 2011-07-09 10:05:00 | This study showed that long PDE4 isoforms provide a novel node for cross-talk between the cAMP and p38 MAPK signalling systems at the level of MK2. | 21323643 |
| 2011-03-11 13:42:00 | Increased cAMP may remodel cAMP-mediated signalling events by not only increasing the expression of specific PDE4 cAMP phosphodiesterases but also by down-regulating specific isoforms, such as is shown here for PDE4A10 in cardiac myocytes. | 18721873 |
| Type | IDs |
|---|---|
| Synonymous | D9Ertd60e, Dpde2 |
| Gene |
UniProtKB-ID:
PDE4A_MOUSE,
Q3TUD0_MOUSE,
B2RTL2_MOUSE
UniprotKB:
O89084,
Q3TUD0,
B2RTL2
UniParc:
UPI00005B1C98,
UPI00000297D2,
UPI000002A6D1,
UPI000002A6D2
EMBL:
AF208021,
AF142644,
AF142645,
U97586,
BC027224,
BC139405,
AJ297396,
AF142646,
BC139408,
AF142643,
AK160843
Ensembl:
ENSMUSG00000032177
KO:
mmu:18577
|
| Nucleutide sequences |
EMBL-CDS:
AAF19201.2,
AAF14519.1,
AAH27224.2,
CAB96769.1,
AAF14520.1,
AAC25681.1,
BAE36041.1,
AAI39406.1,
AAI39409.1
Ensembl_TRS:
ENSMUST00000003395,
ENSMUST00000115458,
ENSMUST00000039413
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000003395,
ENSMUSP00000111118,
ENSMUSP00000037025
RefSeq:
XP_030099987.1,
XP_006510156.1,
XP_006510154.1,
NP_899668.1,
XP_030099986.1,
XP_017168700.1,
NP_062772.3,
NP_001297679.1
|
| Others |
UniRef100:
UniRef100_Q3TUD0,
UniRef100_O89084
UniRef90:
UniRef90_P54748,
UniRef90_P54748-6
UniRef50:
UniRef50_P27815-3,
UniRef50_P27815-7
UniGene:
Mm.191749
CCDS:
CCDS22896.1,
CCDS22895.1,
CCDS80964.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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