| Type | Description |
|---|---|
| Definition | phosphodiesterase 1B, Ca2+-calmodulin dependent |
| Date | Results | Publications |
|---|---|---|
| 2018-02-24 10:32:00 | New Floxed Pde1b x CreCMV global knockout (KO) mice demonstrate depression-like behavioral resistance separate from stress-related effects. | 28488329 |
| 2018-01-27 10:11:00 | Pde1b knock-out mice exhibited decreased tail suspension test and forced swim test immobilization; a model for depression. | 28337525 |
| 2010-10-14 10:36:00 | These results prove that the kinetic properties of PDE isoforms play a major role in determining intracellular cAMP signals in response to physiological elevation of [Ca2+]i. | 18335582 |
| 2010-01-21 00:00:00 | Data suggest a role for PDE1B in locomotor responses to psychostimulants through modulation of pathways; however, this modulation does not necessarily impact other behaviors, such as anxiety or learning. | 17010100 |
| 2010-01-21 00:00:00 | knock-out mice exhibit locomotor hyperactivity in response to dopamine agonists and display impaired spatial learning | 12077213 |
| Type | IDs |
|---|---|
| Synonymous | Pde1b1 |
| Gene |
UniProtKB-ID:
PDE1B_MOUSE,
Q9DBS6_MOUSE,
Q6PDS5_MOUSE,
A0A2I3BPC1_MOUSE
UniprotKB:
Q01065,
Q9DBS6,
Q6PDS5,
A0A2I3BPC1
UniParc:
UPI00000E7C2A,
UPI0003B9303F,
UPI00001D3F74,
UPI0000021F15
EMBL:
M94538,
BC058531,
AC131721,
AK004772,
L01695,
AH007066
Ensembl:
ENSMUSG00000022489
KO:
mmu:18574
|
| Nucleutide sequences |
EMBL-CDS:
AAA39902.1,
AAC96022.1,
AAA37367.1,
BAB23551.1,
AAH58531.1
Ensembl_TRS:
ENSMUST00000023132,
ENSMUST00000226468,
ENSMUST00000227955
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000023132,
ENSMUSP00000153865,
ENSMUSP00000153722
RefSeq:
NP_001272819.1,
NP_001344909.1,
NP_032826.1,
XP_030104267.1
|
| Others |
UniRef100:
UniRef100_A0A2I3BPC1,
UniRef100_Q01065,
UniRef100_Q6PDS5
UniRef90:
UniRef90_Q01065
UniRef50:
UniRef50_Q01064-2
UniGene:
Mm.390792
CCDS:
CCDS27904.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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