| Type | Description |
|---|---|
| Definition | phosphodiesterase 1A, calmodulin-dependent |
| Date | Results | Publications |
|---|---|---|
| 2020-07-25 10:24:00 | PDE1 inhibition induces and PKG-mediated promotion of proteasomal degradation of misfolded proteins and treats heart failure with preserved ejection fraction caused by CryAB(R120G) in a mouse model of cardiac proteinopathy | 31131329 |
| 2017-09-30 10:42:00 | These results support an important role of PDE1A in the renal pathogenesis of autosomal dominant polycystic kidney disease and in the regulation of blood pressure. | 28750036 |
| 2012-03-31 10:05:00 | These results suggest that induction of PDE1A plays a critical role in cardiac fibroblast activation and cardiac fibrosis | 22012077 |
| 2010-10-14 10:36:00 | These results prove that the kinetic properties of PDE isoforms play a major role in determining intracellular cAMP signals in response to physiological elevation of [Ca2+]i. | 18335582 |
| 2010-01-21 00:00:00 | a novel role for Ca(2+)/CaM-stimulated PDE1, particularly PDE1A, in regulating pathological cardiomyocyte hypertrophy via a cGMP/PKG-dependent mechanism, thereby demonstrating Ca(2+) and cGMP signaling cross-talk during cardiac hypertrophy. | 19797176 |
| Type | IDs |
|---|---|
| Synonymous | AI987702, AW125737 |
| Gene |
UniProtKB-ID:
PDE1A_MOUSE
UniprotKB:
Q61481
UniParc:
UPI000002A6C8,
UPI00004B2B24,
UPI00000EADAC,
UPI00000E65AE
EMBL:
AK043647,
AL928811,
BC090628,
AL844577,
AF023529,
AY845864,
CH466519,
U56649,
AL928607,
AF159298
Ensembl:
ENSMUSG00000059173
KO:
mmu:18573
|
| Nucleutide sequences |
EMBL-CDS:
EDL27256.1,
AAW31879.1,
AAH90628.1,
EDL27257.1,
AAB03319.1,
AAF63857.1,
AAB81952.1,
EDL27255.1,
BAC31606.1
Ensembl_TRS:
ENSMUST00000102654,
ENSMUST00000102652,
ENSMUST00000183775,
ENSMUST00000102651,
ENSMUST00000102653,
ENSMUST00000102655
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000099715,
ENSMUSP00000139327,
ENSMUSP00000099713,
ENSMUSP00000099712,
ENSMUSP00000099711,
ENSMUSP00000099714
RefSeq:
NP_001009978.1,
XP_006498982.1,
NP_001342070.1,
NP_001342071.1,
NP_001342073.1,
XP_011237658.1,
XP_036015425.1,
XP_030104296.1,
NP_058024.2,
NP_001009979.1,
NP_001153054.1,
NP_001342069.1
|
| Others |
UniRef100:
UniRef100_Q61481
UniRef90:
UniRef90_Q61481
UniRef50:
UniRef50_P54750
UniGene:
Mm.40678
CCDS:
CCDS16172.1,
CCDS16174.1,
CCDS16173.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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