| Type | Description |
|---|---|
| Definition | dishevelled segment polarity protein 3 |
| Date | Results | Publications |
|---|---|---|
| 2020-10-03 11:45:00 | The NEK2 triggered phosphorylation of PDZ domain at S263 and S280 prevents binding of DVL3 C-terminus to PDZ and promotes an open conformation of DVL3 that is more prone to even subcellular localization. | 31870452 |
| 2019-11-16 11:13:00 | down-regulation of Dvl3 expression can control the progression of esophageal squamous cell carcinoma, inhibit the growth and promote the apoptosis of tumor cells | 30536315 |
| 2019-11-02 10:50:00 | The interaction between Dvl3 allelic variations and negative life events. | 30242173 |
| 2019-06-01 10:06:00 | In silico modeling and in vitro biophysical methods explain how CK1epsilon-specific phosphorylation events control conformational dynamics of DVL3 in living cells upon Wnt pathway stimulation via modulation of the PDZ domain and its interaction with DVL3 C-terminus. | 31000703 |
| 2019-03-09 12:24:00 | downregulation of ASPM expression pronouncedly attenuated the proliferation, colony formation, and the invasive behavior of PCA cells, and dramatically reduced the number of ALDH(+) CSCs and inhibited cancer stemness and tumorigenicity. Mechanistically, ASPM interacts with disheveled-3 (Dvl-3), a cardinal upstream regulator of canonical Wnt signaling, and inhibits its proteasome-dependent degradation | 30266990 |
| Type | IDs |
|---|---|
| Synonymous | DRS3 |
| Gene |
UniProtKB-ID:
DVL3_HUMAN,
Q9UG07_HUMAN
UniprotKB:
Q92997,
Q9UG07
UniParc:
UPI00017A8652,
UPI00001299A9,
UPI00000710D0
EMBL:
AC131235,
BC032459,
U49262,
U75651,
AL110278,
AF006013,
CH471052,
D86963,
AK304686
Ensembl:
ENSG00000161202
KO:
hsa:1857
|
| Nucleutide sequences |
EMBL-CDS:
EAW78295.1,
AAB47447.1,
BAG65457.1,
AAB65244.1,
EAW78296.1,
AAB84228.1,
AAH32459.1,
BAA13199.2,
CAB53713.1,
EAW78294.1
Gene_ORFName:
hCG_40299
Ensembl_TRS:
ENST00000431765,
ENST00000313143
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000316054,
ENSP00000405885
RefSeq:
XP_011510815.1,
XP_005247229.1,
NP_004414.3
|
| Others |
UniRef100:
UniRef100_Q9UG07,
UniRef100_Q92997
UniRef90:
UniRef90_Q9UG07,
UniRef90_Q92997
UniRef50:
UniRef50_A0A384D9W6,
UniRef50_Q92997
UniGene:
Hs.388116
CCDS:
CCDS3253.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员