| Type | Description |
|---|---|
| Definition | proprotein convertase subtilisin/kexin type 5 |
| Date | Results | Publications |
|---|---|---|
| 2019-03-23 11:58:00 | this study demonstrates that Pcsk5 is expressed in bone-forming cells, and that OPN is a novel substrate for PC5/6 | 29126984 |
| 2018-04-14 12:03:00 | Pcsk5 may have an essential and early role in the cranio-cardiac mesoderm for heart development. | 28446132 |
| 2017-07-08 12:42:00 | loss of the convertase furin or PC5/6 in hepatocytes results in a approximately 30% decrease in APC levels, with no significant contribution from PACE4. We conclude that prior convertase cleavage of protein C in hepatocytes is critical for its thrombin activation. | 28468828 |
| 2013-09-28 11:24:00 | overexpression of PCs, furin and PC5, but not PC7, which are all expressed in SMC, increase PKGI cleavage in a dose-dependent manner | 23686857 |
| 2012-02-04 10:05:00 | Inactivation of endothelial proprotein convertase 5/6 decreases collagen deposition in the cardiovascular system: role of fibroblast autophagy. | 21681612 |
| Type | IDs |
|---|---|
| Synonymous | PC5, PC6, SPC6, b2b1549Clo, b2b585Clo |
| Gene |
UniProtKB-ID:
PCSK5_MOUSE,
Q91VK0_MOUSE
UniprotKB:
Q04592,
Q91VK0
UniParc:
UPI00000E5C1D,
UPI0000022409
EMBL:
D17583,
D12619,
L14932,
AC126940,
AC147369,
BC013068,
AC125203,
AC133509
Ensembl:
ENSMUSG00000024713
KO:
mmu:18552
|
| Nucleutide sequences |
EMBL-CDS:
BAA04507.1,
BAA02143.1,
AAA74636.1,
AAH13068.1
Ensembl_TRS:
ENSMUST00000025618,
ENSMUST00000050715
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000050272,
ENSMUSP00000025618
RefSeq:
XP_036017351.1,
NP_001177412.1,
XP_006526823.1,
XP_006526822.1,
XP_006526824.1,
NP_001156616.1,
XP_011245464.1
|
| Others |
UniRef100:
UniRef100_Q04592,
UniRef100_Q91VK0
UniRef90:
UniRef90_Q91VK0,
UniRef90_Q04592
UniRef50:
UniRef50_Q92824,
UniRef50_Q91VK0
UniGene:
Mm.3401
CCDS:
CCDS50402.1,
CCDS50401.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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