| Type | Description |
|---|---|
| Definition | proprotein convertase subtilisin/kexin type 4 |
| Date | Results | Publications |
|---|---|---|
| 2013-01-26 11:44:00 | CRES may be a regulator of PC4 in sperm-egg interaction and fertilization. | 22827436 |
| 2012-09-29 10:41:00 | Data suggest that the fertility defect in PCSK4 knockout mice is due, in part, to altered processing/proteolysis of ACRBP (proacrosin/acrosin binding protein sp32) as well as structural abnormalities in sperm heads and acrosomes. | 22357636 |
| 2011-11-19 11:39:00 | thatADAM2may be a natural substrate of sperm PCSK4 and its cleavage by the enzyme during acrosome reaction may be relevant to the fertilization process. | 21302280 |
| 2011-04-23 11:15:00 | Efficient activation and trafficking of PCSK4 requires a special environment, which presumably exists in testicular germ cells where it is highly expressed, but not in somatic cells where it is not or is barely expressed. | 21080038 |
| 2010-04-12 11:38:00 | Alterations in signal transduction and proteolytic processing during in vitro capacitation may underlie the fertilization incompetence of PCSK4-null sperm. | 19342015 |
| Type | IDs |
|---|---|
| Synonymous | AI647044, L21221, NEC 3, NEC3, PC4, SPC5 |
| Gene |
UniProtKB-ID:
PCSK4_MOUSE
UniprotKB:
P29121
UniParc:
UPI00000287FE,
UPI0000403182,
UPI0000403180,
UPI000040317F,
UPI000040317D,
UPI0000403181,
UPI000040317E,
UPI000040317C
EMBL:
L21212,
L21215,
L21221,
D01093,
L21217,
L21222,
L21216,
L21223,
L21210,
L21219,
L21214,
L21211,
L21213,
L21218,
L21220
Ensembl:
ENSMUSG00000020131
KO:
mmu:18551
|
| Nucleutide sequences |
EMBL-CDS:
AAA39973.1,
BAA00877.1
Ensembl_TRS:
ENSMUST00000020340
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000020340
RefSeq:
XP_006513427.1,
XP_006513422.1,
XP_006513421.1,
XP_006513431.1,
NP_032819.1,
XP_036011582.1,
XP_006513432.1,
XP_006513424.1,
XP_006513428.1,
XP_006513425.1,
XP_006513426.1,
XP_006513423.1,
XP_030100811.1
|
| Others |
UniRef100:
UniRef100_P29121
UniRef90:
UniRef90_P29121
UniRef50:
UniRef50_P29121
UniGene:
Mm.299916
CCDS:
CCDS24018.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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