| Type | Description |
|---|---|
| Definition | furin (paired basic amino acid cleaving enzyme) |
| Date | Results | Publications |
|---|---|---|
| 2021-02-02 13:25:00 | Loss of the proprotein convertase Furin in T cells represses mammary tumorigenesis in oncogene-driven triple negative breast cancer. | 32389711 |
| 2020-01-18 10:29:00 | Administering the furin inhibitor alpha-1-PDX to Apoe(-/-) mice harboring a wire injury in the common carotid artery caused decreased carotid intimal thickness and lower plaque cellularity, smooth muscle cell, macrophage, and inflammatory marker content, suggesting protection against vascular remodeling. FURIN overexpression increased intimal plaque thickness 67%.FURIN levels directly correlate with atherosclerosis. | 30651003 |
| 2019-12-14 11:29:00 | Study shows that Nkx2-5 directly represses cardiac Furin expression. Furthermore, Furin is required for the maturation of the cardiac progenitor cells and for the correct formation of the atrioventricular junction where it is expressed. Finally, study shows that this function is, at least in part, mediated by modulation of the BMP pathway. | 30840660 |
| 2019-08-10 12:24:00 | The results showed that a protein called Furin activates Dispatched by splitting it at a specific point. When the break-point on Dispatch was genetically modified, Furin could no longer cleave the protein. As a consequence, Dispatched did not reach the correct location within cells to help Hedgehog move away from signal-releasing cells. | 29359685 |
| 2019-07-27 10:25:00 | Coronary artery disease-associated genetic variant increases FURIN expression, promoting monocyte/macrophage migration and proliferation while inhibiting apoptosis. | 29976768 |
| Type | IDs |
|---|---|
| Synonymous | 9130404I01Rik, Fur, PACE, Pcsk3, SPC1 |
| Gene |
UniProtKB-ID:
FURIN_MOUSE
UniprotKB:
P23188
UniParc:
UPI0000023512
EMBL:
L26489,
CH466543,
BC048234,
X54056
Ensembl:
ENSMUSG00000030530
KO:
mmu:18550
|
| Nucleutide sequences |
EMBL-CDS:
CAA37988.1,
AAA37643.1,
AAH48234.1,
EDL06988.1
Ensembl_TRS:
ENSMUST00000120753,
ENSMUST00000107362,
ENSMUST00000122232
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000102985,
ENSMUSP00000113793,
ENSMUSP00000113370
RefSeq:
XP_011249121.1,
XP_011249120.1,
XP_030098069.1,
NP_001074923.1,
XP_011249124.1,
XP_011249125.1,
XP_011249123.1,
XP_011249122.1,
XP_030098070.1,
NP_035176.1
|
| Others |
UniRef100:
UniRef100_P23188
UniRef90:
UniRef90_P23188
UniRef50:
UniRef50_P09958
UniGene:
Mm.5241
CCDS:
CCDS21397.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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