| Type | Description |
|---|---|
| Definition | pregnancy-associated plasma protein A |
| Date | Results | Publications |
|---|---|---|
| 2021-02-06 13:58:00 | Genetic and Pharmacological Inhibition of PAPP-A Protects Against Visceral Obesity in Mice. | 32888014 |
| 2020-06-20 11:44:00 | This work provides a comprehensive characterization of the surfaceome of EWS, credentials PAPP-A as a highly differentially expressed therapeutic target, and discovers a novel link between IGF-1 signaling and immune evasion in cancer, thus implicating shared mechanisms of immune evasion between EWS and the placenta. | 30698726 |
| 2017-12-02 11:57:00 | Inducible knockdown of PAPP-A gene expression in adult female mice extends life span. | 28600811 |
| 2017-09-30 11:20:00 | Intrinsic mitochondrial oxidative capacity was significantly increased in skeletal muscle of aged PAPP-A KO compared to WT mice. Moreover, 18-month-old PAPP-A KO mice exhibited significantly enhanced endurance running on a treadmill. Thus, PAPP-A deficiency in mice is associated with indices of healthy skeletal muscle function with age. | 27086066 |
| 2017-06-10 10:13:00 | Snell, GHKRO, and PAPPA-KO mice express high levels of two proteins involved in DNA repair, O-6-methylguanine-DNA methyltransferase (MGMT) and N-myc downstream-regulated gene 1 (NDRG1). | 27618784 |
| Type | IDs |
|---|---|
| Synonymous | 8430414N03Rik, IGFBP-4ase, PAG1, PAPP-A |
| Gene |
UniProtKB-ID:
PAPP1_MOUSE
UniprotKB:
Q8R4K8
UniParc:
UPI0000470ED1,
UPI0000470582
EMBL:
AF510317,
AF439514,
AL691491,
AF260433,
AF258461,
AF439513,
AL691454
Ensembl:
ENSMUSG00000028370
KO:
mmu:18491
|
| Nucleutide sequences |
EMBL-CDS:
AAG09799.1,
AAM44048.1,
AAF70319.1,
AAM12688.1,
AAM12687.1
Ensembl_TRS:
ENSMUST00000084501
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000081545
RefSeq:
NP_067337.1
|
| Others |
UniRef100:
UniRef100_Q8R4K8
UniRef90:
UniRef90_Q8R4K8
UniRef50:
UniRef50_Q13219
UniGene:
Mm.317854
CCDS:
CCDS18267.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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