| Type | Description |
|---|---|
| Definition | p21 (RAC1) activated kinase 3 |
| Date | Results | Publications |
|---|---|---|
| 2019-03-09 11:15:00 | Furthermore, pharmacological inhibition of PAKs decreases ATXN1 levels in a mouse model of SCA1. To explore the potential of using PAK inhibitors in combination therapy, we combined the pharmacological inhibition of PAK with MSK1, a previously identified modulator of ATXN1, and examined their effects on ATXN1 levels. We found that inhibition of both pathways results in an additive decrease in ATXN1 levels. | 29860311 |
| 2018-03-03 10:51:00 | Pak3 knockout (KO) mice had defects of oligodendrocyte differentiation in developing corpus callosum and to a lesser extent in anterior commissure, which were compensated at the adult stage. In vitro experiments in oligodendrocyte precursor (OPC) cultures, derived from Pak3 KO and wild type brains, support a developmental and cell-autonomous role for PAK3 in regulating OPC differentiation into mature oligodendrocytes. | 27940202 |
| 2014-03-01 11:41:00 | Our results indicate that Pak3 is a novel regulator of beta-cell differentiation and function. Pak3 acts downstream of Ngn3 to promote cell cycle exit and differentiation in the embryo by a mechanism that might involve repression of Ccnd1. | 24163148 |
| 2013-06-08 10:56:00 | Pak proteins are key components of multiple engraftment-associated hematopoietic stem cells functions and play a direct role in activation of ERK in hematopoietic stem cells. | 23335370 |
| 2012-11-24 10:38:00 | PAK1 inhibits the activity of PAK3a but not of the splice variant PAK3b in a trans-regulatory manner. Altogether, these results show that PAK3 and PAK1 signaling may be coordinated by heterodimerization. | 22815483 |
| Type | IDs |
|---|---|
| Synonymous | PAK-3, Pak65alpha, Pak65beta, Stk4 |
| Gene |
UniProtKB-ID:
PAK3_MOUSE,
B1GX81_MOUSE,
B1GX80_MOUSE
UniprotKB:
Q61036,
B1GX81,
B1GX80
UniParc:
UPI0000023725,
UPI0001718206,
UPI00000E88A7,
UPI0000219401
EMBL:
AF082297,
AK031853,
AM943853,
AJ496263,
AM943854,
U39738,
BC053403,
AJ496262
Ensembl:
ENSMUSG00000031284
KO:
mmu:18481
|
| Nucleutide sequences |
EMBL-CDS:
AAH53403.1,
CAD42790.1,
BAC27580.1,
AAC31969.1,
CAD42791.1,
AAC52354.1,
CAQ16020.1,
CAQ16019.1
Ensembl_TRS:
ENSMUST00000112864,
ENSMUST00000112865,
ENSMUST00000112863,
ENSMUST00000172330,
ENSMUST00000112868,
ENSMUST00000033640
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000108485,
ENSMUSP00000108486,
ENSMUSP00000108484,
ENSMUSP00000126562,
ENSMUSP00000108489,
ENSMUSP00000033640
RefSeq:
NP_001181977.1,
NP_001181978.1,
XP_030107111.1,
XP_006528817.1,
XP_030107109.1,
XP_030107110.1,
XP_011246092.1,
XP_036017734.1,
XP_036017739.1,
XP_036017735.1,
XP_036017741.1,
XP_036017740.1,
XP_036017738.1,
XP_036017736.1,
NP_001181975.1,
NP_032804.2,
XP_006528815.1,
XP_006528816.1,
XP_030107108.1,
NP_001181976.1,
XP_036017737.1
|
| Others |
UniRef100:
UniRef100_B1GX81,
UniRef100_B1GX80,
UniRef100_Q61036
UniRef90:
UniRef90_G1P1A0,
UniRef90_Q62829,
UniRef90_O75914
UniRef50:
UniRef50_Q13177,
UniRef50_G1P1A0
UniGene:
Mm.40035
CCDS:
CCDS57779.1,
CCDS30454.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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