| Type | Description |
|---|---|
| Definition | RHo Guanine nucleotide exchange Factor |
| Date | Results | Publications |
|---|---|---|
| 2019-11-09 13:05:00 | Genetic interactions are consistent with RHO-1 and RHGF-1 acting with UNC-5, as well as with a parallel pathway, to regulate protrusion. The cytoskeletal interacting molecule UNC-33/CRMP was required for RHO-1 activity to inhibit MT accumulation, suggesting that UNC-33/CRMP might act downstream of RHO-1. In sum, these studies describe a new role of RHO-1 and RHGF-1 in regulation of growth cone protrusion by UNC-6/Netrin | 31233487 |
| 2015-04-25 10:25:00 | Independent of myosin light chain activation, RHGF-1 acts via Rho-dependent kinase LET-502/ROCK and activates a conserved, retrograde DLK-1 MAPK pathway, triggering synaptic branch retraction and overgrowth of the PLM neurite in a dose-dependent manner. | 25359212 |
| 2012-09-29 10:20:00 | we show that TIAM-1 acts with UNC-40/DCC in axon guidance, suggesting that TIAM-1 might regulate growth cone protrusion via Rac GTPases in response to UNC-40/DCC | 22570618 |
| 2010-01-21 00:00:00 | The upstream GPA-12/RHGF-1 pathway stimulates only a subset of RHO-1 downstream effectors, suggesting that either the RHO-1 effectors require different levels of activated RHO-1 or there are two distinct pools of RHO-1 within C. elegans neurons. | 17139250 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
G5EFE1_CAEEL
UniprotKB:
G5EFE1
UniParc:
UPI00006975AC
EMBL:
BX284606
EnsemblGenome:
WBGene00006468
KO:
cel:CELE_F13E6.6
|
| Nucleutide sequences |
EMBL-CDS:
CAA92119.4
Gene_ORFName:
F13E6.6,
CELE_F13E6.6
|
| Protein sequencees |
RefSeq:
NP_509791.4
|
| Others |
UniRef100:
UniRef100_G5EFE1
UniRef90:
UniRef90_A8WXP4
UniRef50:
UniRef50_A8WXP4
UniGene:
Cel.19990
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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