| Type | Description |
|---|---|
| Definition | purinergic receptor P2X, ligand-gated ion channel 4 |
| Date | Results | Publications |
|---|---|---|
| 2021-01-02 12:48:00 | P2X4 Receptors on Muscle Macrophages Are Required for Development of Hyperalgesia in an Animal Model of Activity-Induced Muscle Pain. | 31898158 |
| 2019-11-02 11:44:00 | Study in P2rx4 knockout and P2rx4 tdTomato reporter mouse model of sepsis demonstrates that, in contrast to the central role of P2X7Rs in killing obligate intracellular bacteria by macrophages, P2X4Rs kill sepsis-causing bacteria, which are not obligate intracellular pathogens, and which include E. coli and S. aureus. | 29875325 |
| 2019-09-28 10:13:00 | the findings support the hypothesis that P2X4Rs play a role in regulation of ethanol intake and that P2X4Rs represent a novel drug target for treatment of alcohol use disorder | 29477921 |
| 2019-09-14 12:38:00 | findings suggest that P2X4 receptors are therapeutic targets for immunomodulation in transplantation and inflammatory diseases. | 29894310 |
| 2019-04-27 11:34:00 | The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with high calcium permeability. The main pharmacological distinction between the members of the purinoceptor family is the relative sensitivity to the antagonists suramin and | 29973381 |
| Type | IDs |
|---|---|
| Synonymous | AI504491, AW555605, D5Ertd444e, P2X4 |
| Gene |
UniProtKB-ID:
D3Z5U5_MOUSE,
D3YYR5_MOUSE,
Q9Z257_MOUSE,
Q9Z256_MOUSE
UniprotKB:
D3Z5U5,
D3YYR5,
Q9Z257,
Q9Z256
UniParc:
UPI00015DF1EF,
UPI0003D7119F,
UPI00000231F7,
UPI00000231F6
EMBL:
AC115728,
AF089751,
AF089752,
JX417451,
BC005597
Ensembl:
ENSMUSG00000029470
KO:
mmu:18438
|
| Nucleutide sequences |
EMBL-CDS:
AFQ41093.1,
AAC95601.1,
AAH05597.1,
AAC95602.1
Ensembl_TRS:
ENSMUST00000142664,
ENSMUST00000139631,
ENSMUST00000031429,
ENSMUST00000081554
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000117193,
ENSMUSP00000118163,
ENSMUSP00000031429,
ENSMUSP00000080269
RefSeq:
NP_001297647.1,
NP_035156.2,
XP_006530259.1,
NP_001297649.1,
XP_036020762.1
|
| Others |
UniRef100:
UniRef100_Q9Z256,
UniRef100_Q9Z257,
UniRef100_D3YYR5,
UniRef100_D3Z5U5
UniRef90:
UniRef90_P51577
UniRef50:
UniRef50_P51577
UniGene:
Mm.290884,
Mm.463383
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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