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18424 Otx2

18424

Otx2

orthodenticle homeobox 2

protein-coding

Mus musculus

基因描述

Type Description
Definition orthodenticle homeobox 2

研究结论

Date Results Publications
2021-03-27 14:43:00 Cell type- and stage-specific expression of Otx2 is regulated by multiple transcription factors and cis-regulatory modules in the retina. 32631829
2021-03-20 13:23:00 Functional and Evolutionary Diversification of Otx2 and Crx in Vertebrate Retinal Photoreceptor and Bipolar Cell Development. 31968244
2020-09-26 13:03:00 Non-cell Autonomous OTX2 Homeoprotein Regulates Visual Cortex Plasticity Through Gadd45b/g. 29771284
2020-06-20 10:39:00 Heterozygous deletion of Otx2, Vax1, or Six3 is sufficient to produce subfertility. Review shows that that all 3 have reduced numbers of GnRH neurons and are subfertile. However, there is specificity to the subfertility by sex and by mechanisms of action. 30261489
2019-12-28 11:32:00 confirmed the requirement for Otx2 in GnRH neuron development, fertility and correct gonadotropin hormone release in Otx2:Lhrh-cre males 30739114

名称对应

Type IDs
Synonymous E130306E05Rik
Gene
UniProtKB-ID: Q8VD35_MOUSE, Q8R0B5_MOUSE
UniprotKB: Q8VD35, Q8R0B5
UniParc: UPI0000021D2B, UPI00000E79A1
EMBL: BC029667, AC166574, BC017609, AK053741, AK081535, BC027104, AK087527
Ensembl: ENSMUSG00000021848
KO: mmu:18424
Nucleutide sequences
EMBL-CDS: AAH17609.1, BAC39913.1, BAC35500.1, BAC38249.1, AAH29667.1, AAH27104.1
Ensembl_TRS: ENSMUST00000122009, ENSMUST00000226501, ENSMUST00000118578, ENSMUST00000227404, ENSMUST00000119070
Protein sequencees
Ensembl_PRO: ENSMUSP00000154264, ENSMUSP00000113930, ENSMUSP00000113690, ENSMUSP00000154066, ENSMUSP00000112532
RefSeq: XP_017171406.1, XP_011243291.1, NP_001273411.1, XP_011243290.1, NP_001347155.1, XP_030103545.1, NP_001273410.1, NP_001273412.1, XP_017171403.1, NP_659090.1, NP_001347154.1
Others
UniRef100: UniRef100_Q8R0B5, UniRef100_Q8VD35
UniRef90: UniRef90_P80206
UniRef50: UniRef50_P80206
UniGene: Mm.134516, Mm.487292

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