| Type | Description |
|---|---|
| Definition | opioid receptor, kappa 1 |
| Date | Results | Publications |
|---|---|---|
| 2018-10-06 10:15:00 | Our results indicate that the stimulation of kappa-opioid receptors in the hippocampus may ameliorate cognitive dysfunction through the activation of the cholinergic system. These findings may offer a therapeutic alternative approach in the treatment of depression patients' symptoms | 29863085 |
| 2018-07-21 10:47:00 | Suggest that peripheral and central MOR and central KOR may be involved in the modulation of scratching behaviour in imiquimod-treated mice. | 28512665 |
| 2018-06-09 11:55:00 | chronic KOR activation increased phosphorylation of NR2B subunit of NMDA at tyrosine 1472 (pNR2B NMDA) in the hippocampus, but not in the cortex. | 27634008 |
| 2018-05-12 12:12:00 | Pre- and postsynaptic colocalization of kappa opioid receptor and D2R supports a role for kappa opioid receptor potentiating both the D2R inhibitory autoreceptor function and the inhibitory action of D2R on efferent medium spiny neurons. Kappa opioid receptor co-activation accelerates D2R sensitization by contributing to decrease dopamine release in the nucleus accumbens. | 28531297 |
| 2018-05-12 10:26:00 | Mechanical allodynia produced by monosodium iodoacetate (MIA) was enhanced in mice lacking KOR or PDYN gene. In contrast with the nociceptive manifestations induced by osteoarthritis, the increased microglial expression on the lumbar section of the spinal cord after MIA administration was similar in KOR-KO, PDYN-KO and WT littermates. Moreover, anhedonic- and anxiolytic-like states were revealed after MIA administration. | 27567942 |
| Type | IDs |
|---|---|
| Synonymous | K-OR-1, KOR, KOR-1, MSL-1, Oprk2, R21 |
| Gene |
UniProtKB-ID:
OPRK_MOUSE,
A0A5F8MP90_MOUSE,
Q3UVW8_MOUSE,
Q14AL5_MOUSE
UniprotKB:
P33534,
A0A5F8MP90,
Q3UVW8,
Q14AL5
UniParc:
UPI0007405204,
UPI00005ABD0E,
UPI0000022737
EMBL:
S77868,
S81111,
AC124029,
S77869,
D31665,
BC116795,
AK136866,
BC119026,
S77872,
L11065
Ensembl:
ENSMUSG00000025905
KO:
mmu:18387
|
| Nucleutide sequences |
EMBL-CDS:
AAA39363.1,
BAA06508.1,
AAB34130.2,
AAP32232.1,
BAE23151.1,
AAI16796.1,
AAI19027.1
Ensembl_TRS:
ENSMUST00000160777,
ENSMUST00000027038,
ENSMUST00000160339,
ENSMUST00000239100
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000124030,
ENSMUSP00000125105,
ENSMUSP00000027038,
ENSMUSP00000158863
RefSeq:
XP_006495533.1,
NP_001191300.1,
NP_035141.1,
NP_001305664.1
|
| Others |
UniRef100:
UniRef100_P33534
UniRef90:
UniRef90_P41145
UniRef50:
UniRef50_P35372-3
UniGene:
Mm.7977
CCDS:
CCDS14809.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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