| Type | Description |
|---|---|
| Definition | desmoglein 3 |
| Date | Results | Publications |
|---|---|---|
| 2020-10-03 12:51:00 | A potential link between desmoglein 3 and epidermal growth factor receptor in oral squamous cell carcinoma and its effect on cetuximab treatment efficacy. | 30907457 |
| 2020-08-22 15:29:00 | The desmosomal cadherin desmoglein-3 acts as a keratinocyte anti-stress protein via suppression of p53. | 31582719 |
| 2020-05-02 11:41:00 | Report have provided evidence that Dsg3 seems to act as a regulator of YAP and phospho-YAP (pYAP) in cell proliferation and in response to mechanical stress via at least one mechanism of forming a complex with pYAP and regulating its cellular localization. | 31835537 |
| 2019-07-27 11:34:00 | Study shows a precise time course of DSG3 endocytosis and keratin retraction in response to pemphigus vulgaris (PV)-IgG, dissecting the temporal relationship of two hallmarks of PV. Results demonstrate that both mechanisms contribute to loss of cell cohesion but appear to be largely independent of each other. | 29922278 |
| 2019-06-08 11:30:00 | These results demonstrate that signaling patterns parallel the clinical phenotype of pemphigus as some mechanisms involved in loss of cell cohesion are caused by antibodies targeting Dsg3 whereas others correlate with autoantibodies against Dsg1. | 28620161 |
| Type | IDs |
|---|---|
| Synonymous | CDHF6, PVA |
| Gene |
UniProtKB-ID:
DSG3_HUMAN
UniprotKB:
P32926
UniParc:
UPI000013CF4B
EMBL:
AK290367,
M76482,
AC021549
Ensembl:
ENSG00000134757
KO:
hsa:1830
|
| Nucleutide sequences |
EMBL-CDS:
AAA60230.1,
BAF83056.1
Ensembl_TRS:
ENST00000257189
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000257189
RefSeq:
NP_001935.2,
XP_011524152.1
|
| Others |
UniRef100:
UniRef100_P32926
UniRef90:
UniRef90_P32926
UniRef50:
UniRef50_P32926
UniGene:
Hs.1925
CCDS:
CCDS11898.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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