| Type | Description |
|---|---|
| Definition | oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) |
| Date | Results | Publications |
|---|---|---|
| 2020-09-26 13:07:00 | Triheptanoin alters [U-(13)C6]-glucose incorporation into glycolytic intermediates and increases TCA cycling by normalizing the activities of pyruvate dehydrogenase and oxoglutarate dehydrogenase in a chronic epilepsy mouse model. | 30890077 |
| 2020-02-01 13:12:00 | chromatin immunoprecipitation-deep sequencing, confirmed the predominant association of OGDH and ACAA2 with H2A.Z-occupied transcription start sites and enhancers, the former of which we confirmed is conserved in both mouse and human tissue | 31682939 |
| 2018-02-10 10:30:00 | We propose that D2-HG promotes cardiac dysfunction by impairing alpha-ketoglutarate dehydrogenase and induces histone modifications in an ACL-dependent manner | 27582470 |
| 2017-12-16 12:24:00 | Taken together, our results indicate that the redox sensing and forming properties of Pdh and Ogdh are linked to S-glutathionylation | 28242228 |
| 2017-11-26 01:43:00 | pre-incubation of permeabilized liver mitochondria from mouse depleted of GSH showed an approximately ~3.5-fold increase in Ogdh-mediated O2(-)/H2O2 production that was matched by a significant decrease in NADH formation which could be reversed by Grx2. Taken together, our results demonstrate GSH and GSSG modulate production by Ogdh through S-glutathionylation of different subunits | 26928132 |
| Type | IDs |
|---|---|
| Synonymous | 2210403E04Rik, 2210412K19Rik, AA409584, d1401, mKIAA4192 |
| Gene |
UniProtKB-ID:
ODO1_MOUSE,
Z4YJV4_MOUSE
UniprotKB:
Q60597,
Z4YJV4
UniParc:
UPI00014F7AEE,
UPI000024F0A7,
UPI00004704CE,
UPI00014F7AED,
UPI0000020D2A
EMBL:
U02971,
BC031165,
BC049104,
AK147289,
BC025040,
BC057354,
AK169286,
AK150009,
BC013670,
AL607152,
BC029143,
AK220536
Ensembl:
ENSMUSG00000020456
KO:
mmu:18293
|
| Nucleutide sequences |
EMBL-CDS:
BAE29234.1,
AAH29143.1,
AAH49104.1,
AAC52130.1,
BAE41044.1,
BAD90530.1,
AAH57354.1,
BAE27824.1,
AAH31165.1,
AAH25040.1,
AAH13670.1
Ensembl_TRS:
ENSMUST00000003461,
ENSMUST00000101554,
ENSMUST00000093350,
ENSMUST00000081894
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000099090,
ENSMUSP00000091041,
ENSMUSP00000003461,
ENSMUSP00000080569
RefSeq:
XP_006514647.1,
XP_030101510.1,
NP_001239216.1,
NP_001239212.1,
NP_035086.2,
NP_001239217.1,
NP_001348833.1,
NP_001348832.1,
XP_030101508.1,
NP_001239211.1,
XP_030101512.1,
XP_030101509.1,
XP_030101511.1,
NP_001348834.1,
XP_036012306.1,
XP_006514645.1,
NP_001348831.1
|
| Others |
UniRef100:
UniRef100_Z4YJV4,
UniRef100_Q60597
UniRef90:
UniRef90_Q60597,
UniRef90_Q60597-2
UniRef50:
UniRef50_Q02218
UniGene:
Mm.276348,
Mm.479411,
Mm.490272
CCDS:
CCDS56758.1,
CCDS36106.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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