| Type | Description |
|---|---|
| Definition | NUMB endocytic adaptor protein |
| Date | Results | Publications |
|---|---|---|
| 2020-10-24 14:12:00 | Numb ameliorates necrosis and inflammation in acute kidney injury induced by cisplatin. | 32888910 |
| 2020-09-05 13:55:00 | EGFR Signaling Termination via Numb Trafficking in Ependymal Progenitors Controls Postnatal Neurogenic Niche Differentiation. | 31433979 |
| 2020-07-04 12:50:00 | Our data suggest that Numb depletion promotes mitochondrial fragmentation by promoting the phosphorylation of Drp1 Ser(637) and thus exacerbates cisplatin-induced mitochondrial dysfunction and tubular cell apoptosis. These findings add a novel insight into modulating mechanism of mitochondrial dynamics during AKI. | 29890853 |
| 2020-03-28 12:17:00 | Cardiomyocyte orientation modulated by the Numb family proteins-N-cadherin axis is essential for ventricular wall morphogenesis. | 31300538 |
| 2020-03-28 10:52:00 | Numb, an endocytic adaptor, binds to Boc and is required for Boc internalization, Shh-mediated growth-cone turning in vitro, and commissural axon guidance in vivo. | 31054872 |
| Type | IDs |
|---|---|
| Synonymous | Nb |
| Gene |
UniProtKB-ID:
NUMB_MOUSE
UniprotKB:
Q9QZS3
UniParc:
UPI000002AFD8,
UPI0000021B4E,
UPI000002AFD7,
UPI0000026576
EMBL:
BC033459,
U70674,
AF169191,
AK004553,
AF169192,
AF170709
Ensembl:
ENSMUSG00000021224
KO:
mmu:18222
|
| Nucleutide sequences |
EMBL-CDS:
BAB23367.1,
AAD47834.1,
AAB09586.1,
AAD47836.1,
AAH33459.1,
AAD47835.1
Ensembl_TRS:
ENSMUST00000154043,
ENSMUST00000117217,
ENSMUST00000129335,
ENSMUST00000021647
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000119303,
ENSMUSP00000113591,
ENSMUSP00000117899,
ENSMUSP00000021647
RefSeq:
XP_006515641.1,
XP_036013140.1,
XP_006515640.1,
NP_001258985.1,
XP_006515639.1,
XP_011242314.1,
NP_001129547.1,
NP_001258984.1,
NP_035079.1,
XP_006515638.2,
XP_006515636.2,
XP_036013141.1,
XP_006515635.2,
XP_006515637.2,
XP_036013139.1
|
| Others |
UniRef100:
UniRef100_Q9QZS3
UniRef90:
UniRef90_Q9QZS3
UniRef50:
UniRef50_Q9QZS3
UniGene:
Mm.4390
CCDS:
CCDS70400.1,
CCDS26032.1,
CCDS49108.1,
CCDS70401.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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