| Type | Description |
|---|---|
| Definition | neutral sphingomyelinase (N-SMase) activation associated factor |
| Date | Results | Publications |
|---|---|---|
| 2013-10-19 13:10:00 | FAN through promoting melanoma cellular motility and tumour invasiveness is critical for the tumour-promoting action of tumor necrosis factor. | 23674089 |
| 2013-07-20 11:53:00 | FAN is not implicated in the development of methionine and choline deficient diet-induced non-alcoholic steatohepatitis. | 23044079 |
| 2010-01-21 00:00:00 | FAN mediates activation of N-SMase as well as regulation of lysosome size by signaling pathways that operate independent from activation/membrane recruitment of | 17512928 |
| 2010-01-21 00:00:00 | these results indicate the involvement of FAN in TNF-induced gene expression and leukocyte recruitment, contributing to the establishment of the specific immune response. | 19786552 |
| 2010-01-21 00:00:00 | This is the first report to demonstrate that TNFalpha-induced sickness behavior is fully mediated by TNF-R1 and that the adaptor protein FAN is a necessary intracellular intermediate for sickness behavior | 18825372 |
| Type | IDs |
|---|---|
| Synonymous | AA959567, C630007J05, Fan |
| Gene |
UniProtKB-ID:
FAN_MOUSE
UniprotKB:
O35242
UniParc:
UPI0000193039
EMBL:
BX510318,
BC145961,
CH466538,
AL772306,
BC145963,
AF013632
Ensembl:
ENSMUSG00000028245
KO:
mmu:18201
|
| Nucleutide sequences |
EMBL-CDS:
AAB65394.1,
EDL05686.1,
AAI45964.1,
AAI45962.1
Ensembl_TRS:
ENSMUST00000029910
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000029910
RefSeq:
XP_006537726.1,
XP_006537725.1,
XP_036019711.1,
NP_035075.2,
XP_006537727.1
|
| Others |
UniRef100:
UniRef100_O35242
UniRef90:
UniRef90_O35242
UniRef50:
UniRef50_Q92636
UniGene:
Mm.3059
CCDS:
CCDS17952.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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