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18191 Nrxn3

18191

Nrxn3

neurexin III

protein-coding

Mus musculus

基因描述

Type Description
Definition neurexin III

研究结论

Date Results Publications
2020-03-28 12:06:00 Alternative splicing of neurexin-3 at SS4 suppressed AMPA-receptor-mediated, but not NMDA-receptor-mediated, synaptic responses. 31005376
2019-07-20 13:12:00 Mice of the 129 strain carry a unique missense variant in neurexin 3 and exhibit a profound and selective enhancement in observational fear. 29681532
2018-06-23 11:04:00 In the present study, we report that Nrxn3beta is processed by the metalloproteases ADAM10, ADAM17, and by the intramembrane-cleaving protease gamma-secretase, producing secreted neurexin3beta (sNrxn3beta) and a single intracellular domain (Nrxn3beta-ICD). Thea authors show that sNrxn3beta produced by the cells of the dentate gyrus increases the spine density of newborn neurons. 27991559
2017-10-28 10:56:00 Nrxn3 is responsible for the neuroligins (NLs)-induced assembly of GABAergic synapses in co-culture. Importantly, lentivirus-based expression of Nrxn3 containing exon 20 restores the reduced NLs-induced GABAergic contacts in the SLM2 E/E co-culture. 28939043
2017-07-29 12:57:00 After pan-neurexin deletions, we observed in these synapses severe but dramatically different synaptic phenotypes that ranged from major impairments in their distribution and function (climbing-fiber synapses) to large decreases in synapse numbers (parvalbumin-positive synapses) and severe alterations in action potential-induced presynaptic Ca(2+) transients (somatostatin-positive synapses). 28472659

名称对应

Type IDs
Gene
UniProtKB-ID: NRX3A_MOUSE, NRX3B_MOUSE, E9Q3Q4_MOUSE
UniprotKB: Q6P9K9, Q8C985, E9Q3Q4
UniParc: UPI0001F797C3, UPI000163E7D8, UPI0001F797C4, UPI00001E7588
EMBL: BC060719, AC115910, CT010588, AC115744, AK032126, CT009725, AK042730, AC115709, CT009613, AC161049, CU041252, AC156637, AC120383, AC155274, AC155231, CAAA01025627, AC154495, CR974583, CR974428, AC171335
Ensembl: ENSMUSG00000066392
KO: mmu:18191
Nucleutide sequences
EMBL-CDS: BAC27716.1, AAH60719.1, BAC31344.1
Ensembl_TRS: ENSMUST00000163134, ENSMUST00000057634, ENSMUST00000167887, ENSMUST00000110130, ENSMUST00000110133
Protein sequencees
Ensembl_PRO: ENSMUSP00000129678, ENSMUSP00000127926, ENSMUSP00000050075, ENSMUSP00000105757, ENSMUSP00000105760
RefSeq: XP_036013133.1, XP_036013126.1, NP_001185516.2, XP_036013124.1, XP_036013125.1, XP_036013122.1, NP_001239003.1, XP_036013134.1, XP_036013123.1, XP_036013138.1, XP_036013130.1, XP_036013135.1, XP_036013127.1, XP_036013129.1, XP_030102465.1, XP_036013132.1, XP_006515619.1, XP_036013136.1, XP_036013137.1, NP_766132.2, XP_030102466.1, XP_036013131.1, XP_006515620.1, XP_036013128.1
Others
UniRef100: UniRef100_Q8C985, UniRef100_Q6P9K9, UniRef100_E9Q3Q4
UniRef90: UniRef90_E9Q3Q4, UniRef90_Q6P9K9, UniRef90_Q8C985
UniRef50: UniRef50_Q07310, UniRef50_Q9HDB5-2, UniRef50_Q9HDB5
UniGene: Mm.425766, Mm.487864
CCDS: CCDS56856.1, CCDS49134.1, CCDS79143.1

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