Nr1i2 - nuclear receptor subfamily 1, group I, member 2-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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18171 Nr1i2

基因描述

Type	Description
Definition	nuclear receptor subfamily 1, group I, member 2

研究结论

Date	Results	Publications
2021-04-13 10:09:00	PXR Functionally Interacts with NF-kappaB and AP-1 to Downregulate the Inflammation-Induced Expression of Chemokine CXCL2 in Mice.	33076328
2020-11-21 13:21:00	Evaluating the Role of the Steroid and Xenobiotic Receptor (SXR/PXR) in PCB-153 Metabolism and Protection against Associated Adverse Effects during Perinatal and Chronic Exposure in Mice.	32352317
2020-10-03 12:55:00	The xenobiotic sensing pregnane X receptor regulates tissue damage and inflammation triggered by C difficile toxins.	31907988
2020-09-12 16:05:00	Phosphorylation Modulates the Coregulatory Protein Exchange of the Pregnane X Receptor.	32205367
2020-02-22 12:33:00	PXR stimulation reduced eNOS expression in cultured endothelial cells from Pxr(+/+) but not Pxr(-/-) mice. The microbial metabolite IPA, via the PXR, plays a key role in regulating endothelial function. Furthermore, antibiotic treatment changes PXR-mediated vascular endothelial responsiveness by upregulating eNOS.	31211619

名称对应

Type	IDs
Synonymous	PXR, PXR.1, PXR.2, PXR1, SXR, mPXR
Gene	UniProtKB-ID: NR1I2_MOUSE, Q0P525_MOUSE UniprotKB: O54915, Q0P525 UniParc: UPI000002B200, UPI0000003F32 EMBL: BC137780, AK018630, AF031814, BC120796 Ensembl: ENSMUSG00000022809 KO: mmu:18171
Nucleutide sequences	EMBL-CDS: AAC39964.1, BAB31316.1, AAI20797.1, AAI37781.1 Ensembl_TRS: ENSMUST00000023504
Protein sequencees	Ensembl_PRO: ENSMUSP00000023504 RefSeq: NP_035066.1, XP_011244141.1, NP_001091874.1, XP_006521911.1, XP_006521909.1, XP_011244142.1, XP_006521910.1
Others	UniRef100: UniRef100_O54915 UniRef90: UniRef90_O54915 UniRef50: UniRef50_O54915 UniGene: Mm.8509 CCDS: CCDS28164.1

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mRNA

Protein

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Description

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全选

Pubmed编号	文献信息	发表日期	相关基因
33076328	PXR Functionally Interacts with NF-ÎºB and AP-1 to Downregulate the Inflammation-Induced Expression of Chemokine CXCL2 in Mice. Cells Maya Okamura , Ryota Shizu , Taiki Abe , Susumu Kodama , Takuomi Hosaka , Takamitsu Sasaki , Kouichi Yoshinari	2020-10-15	-
32798464	PXR phosphorylated at Ser350 transduces a glucose signal to repress the estrogen sulfotransferase gene in human liver cells and fasting signal in mouse livers. Biochem Pharmacol Hao Hu , Kosuke Yokobori , Masahiko Negishi	2020-10-01	-
32205367	Phosphorylation Modulates the Coregulatory Protein Exchange of the Nuclear Receptor Pregnane X Receptor. J Pharmacol Exp Ther Wenqi Cui , Xunan Shen , Emre Agbas , Brandon Tompkins , Hadley Cameron-Carter , Jeff L Staudinger	2020-06-01	-
32352317	Evaluating the Role of the Steroid and Xenobiotic Receptor (SXR/PXR) in PCB-153 Metabolism and Protection against Associated Adverse Effects during Perinatal and Chronic Exposure in Mice. Environ Health Perspect Riann Jenay Egusquiza , Maria Elena Ambrosio , Shuyi Gin Wang , Kaelen Marie Kay , Chunyun Zhang , Hans-Joachim Lehmler , Bruce Blumberg	2020-04-01	-
31907988	The xenobiotic sensing pregnane X receptor regulates tissue damage and inflammation triggered by C difficile toxins. FASEB J Sarah L Erickson , Laurie Alston , Kristoff Nieves , Thomas K H Chang , Sridhar Mani , Kyle L Flannigan , Simon A Hirota	2020-02-01	-
31875848	Microbial bile acid metabolites modulate gut RORÎ³⁺Â regulatory T cell homeostasis. Nature Xinyang Song , Ximei Sun , Sungwhan F Oh , Meng Wu , Yanbo Zhang , Wen Zheng , Naama Geva-Zatorsky , Ray Jupp , Diane Mathis , Christophe Benoist , Dennis L Kasper	2020-01-01	-
31374856	Gene Expression Profiling Reveals that PXR Activation Inhibits Hepatic PPARÎ± Activity and Decreases FGF21 Secretion in Male C57Bl6/J Mice. Int J Mol Sci Sharon Ann Barretto , FrÃ©dÃ©ric Lasserre , Anne Fougerat , Lorraine Smith , Tiffany Fougeray , CÃ©line Lukowicz , Arnaud Polizzi , Sarra Smati , Marion RÃ©gnier , Claire Naylies , Colette BÃ©touliÃ¨res , Yannick Lippi , HervÃ© Guillou , Nicolas Loiseau , Laurence Gamet-Payrastre , Laila Mselli-Lakhal , Sandrine Ellero-Simatos	2019-08-01	-
31211619	The pregnane X receptor and its microbiota-derived ligand indole 3-propionic acid regulate endothelium-dependent vasodilation. Am. J. Physiol. Endocrinol. Metab. Vivek Krishna Pulakazhi Venu , Mahmoud Saifeddine , Koichiro Mihara , Yi-Cheng Tsai , Kristoff Nieves , Laurie Alston , Sridhar Mani , Kathy D McCoy , Morley D Hollenberg , Simon A Hirota	2019-08-01	-
30910785	An Extensively Humanized Mouse Model to Predict Pathways of Drug Disposition and Drug/Drug Interactions, and to Facilitate Design of Clinical Trials. Drug Metab Dispos C J Henderson , Y Kapelyukh , N Scheer , A Rode , A W McLaren , A K MacLeod , D Lin , J Wright , L A Stanley , C R Wolf	2019-06-01	-
30573465	Suppression of Hepatic CYP3A4 Expression and Activity by 3-Methylcholanthrene in Humanized PXR-CAR-CYP3A4/3A7 Mice. Drug Metab. Dispos. Michael Crosby , David S Riddick	2019-03-01	-

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