| Type | Description |
|---|---|
| Definition | Nuclear hormone receptor family member daf-12 |
| Date | Results | Publications |
|---|---|---|
| 2020-02-29 11:34:00 | DAF-12 nuclear hormone receptor pathway functions cell-intrinsically in the dauer diapause to arrest neuron morphological aging. | 31589601 |
| 2018-05-26 10:13:00 | that CYP-37A1 (ortholog of human cytochrome P450 CYP4V2), EMB-8 (ortholog of human P450 oxidoreductase POR), and DAF-12 (homolog of human nuclear receptors VDR/LXR) constitute a hormone synthesis and nuclear receptor pathway in Caenorhabditis elegans. | 28760992 |
| 2017-06-03 10:48:00 | Pdda is abolished by synthetic ascarosides and steroidal ligands of the nuclear hormone receptor DAF-12. We show that neither ascarosides nor any known steroid hormones are required for Pdda and that another chemical signal mediates this phenotype, in part via the nuclear hormone receptor NHR-8. | 28394895 |
| 2017-05-27 11:07:00 | We consider irg-7 to be an integral downstream component of the germline longevity pathway because its expression increases upon germ cell removal and its depletion interferes with the activation of the longevity-promoting transcription factors DAF-16 and DAF-12 in germlineless animals. | 28196094 |
| 2017-05-27 10:16:00 | When bound to its ligand, DAF-12 acquires transcriptional activity that directs reproductive development, while unliganded DAF-12 forms a dauer-specifying complex with its interacting protein DIN-1S to regulate the transcription of genes required for dauer development | 27260305 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
DAF12_CAEEL
UniprotKB:
G5EFF5
UniParc:
UPI00004B9D17,
UPI000007F11E,
UPI0000083256,
UPI00000825FE
EMBL:
BX284606,
AF136240,
AF136239,
AF136238
EnsemblGenome:
WBGene00000908
KO:
cel:CELE_F11A1.3
|
| Nucleutide sequences |
EMBL-CDS:
AAD34464.1,
CAJ43436.1,
CAC42285.1,
AAD34463.1,
CAC42284.1,
CAC42283.1,
AAD34462.1
Gene_ORFName:
F11A1.3
EnsemblGenome_TRS:
F11A1.3a.1,
F11A1.3b.1,
F11A1.3d.1,
F11A1.3c.1
|
| Protein sequencees |
EnsemblGenome_PRO:
F11A1.3b.1,
F11A1.3d.1,
F11A1.3c.1,
F11A1.3a.1
RefSeq:
NP_001366986.1,
NP_001041239.1,
NP_001024547.1,
NP_001366987.1
|
| Others |
UniRef100:
UniRef100_G5EFF5
UniRef90:
UniRef90_G5EFF5
UniRef50:
UniRef50_G5EFF5
UniGene:
Cel.18135
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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