| Type | Description |
|---|---|
| Definition | Netrin unc-6 |
| Date | Results | Publications |
|---|---|---|
| 2019-11-09 13:05:00 | Genetic interactions are consistent with RHO-1 and RHGF-1 acting with UNC-5, as well as with a parallel pathway, to regulate protrusion. The cytoskeletal interacting molecule UNC-33/CRMP was required for RHO-1 activity to inhibit MT accumulation, suggesting that UNC-33/CRMP might act downstream of RHO-1. In sum, these studies describe a new role of RHO-1 and RHGF-1 in regulation of growth cone protrusion by UNC-6/Netrin | 31233487 |
| 2019-11-09 10:52:00 | Our results also show that dendrite length is determined by the antagonistic effects on the actin cytoskeleton of separate sets of effectors for retraction mediated by UNC-6(Netrin) versus outgrowth promoted by the DMA-1 receptor. | 31220078 |
| 2019-07-06 12:55:00 | C. elegans Netrin ortholog UNC-6, signaling through its cognate receptor UNC-40/DCC and the CED-5/DOCK180 guanine nucleotide exchange factor, is both required and sufficient for male-specific synaptic maintenance. The dimorphism of unc-6 activity is brought about by sex-specific regulation of unc-6 transcription. | 29429615 |
| 2017-10-14 13:09:00 | rom these studies we conclude that FMO-1, FMO-4, FMO-5, and EHBP-1 represent new players downstream of UNC-6/Netrin receptors and Rac GTPases that inhibit growth cone filopodial protrusion in repulsive axon guidance | 28859089 |
| 2017-10-07 10:36:00 | the ENU-3 family proteins function in a pathway parallel to the UNC-6/Netrin pathway for motor neuron axon outgrowth, most likely in the Wnt pathway. | 28694018 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
UNC6_CAEEL
UniprotKB:
P34710
UniParc:
UPI0000137C59
EMBL:
M80241,
BX284606
EnsemblGenome:
WBGene00006746
KO:
cel:CELE_F41C6.1
|
| Nucleutide sequences |
EMBL-CDS:
CCD67895.1,
AAA28157.1
Gene_ORFName:
F41C6.1
EnsemblGenome_TRS:
F41C6.1.2,
F41C6.1.1
|
| Protein sequencees |
EnsemblGenome_PRO:
F41C6.1.1,
F41C6.1.2
RefSeq:
NP_509165.1
|
| Others |
UniRef100:
UniRef100_P34710
UniRef90:
UniRef90_P34710
UniRef50:
UniRef50_P34710
UniGene:
Cel.6945
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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