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180929 svh-2

180929

svh-2

Tyrosine-protein kinase receptor svh-2

protein-coding

Caenorhabditis elegans

基因描述

Type Description
Definition Tyrosine-protein kinase receptor svh-2

研究结论

Date Results Publications
2020-02-15 10:53:00 Overexpression of svh-2, but not of ddr-2, can suppress the axon regeneration defect observed in svh-11 mutants, suggesting that SVH-11 functions between DDR-2 and SVH-2 in this glycosylation pathway. Furthermore, we found that DDR-2 is N-glycosylated at the Asn-141 residue located in its discoidin domain, and mutation of this residue caused an axon regeneration defect. 31371405
2017-05-13 21:39:00 the scaffold protein SHC-1 interacts with both DDR-2 and SVH-2. Furthermore, we demonstrate that overexpression of svh-2 and shc-1 suppresses the delay in axon regeneration observed in ddr-2 mutants, suggesting that DDR-2 functions upstream of SVH-2 and SHC-1 27984580
2016-06-04 10:49:00 We show that phosphorylation of ETS-4 promotes its complex formation with CEBP-1. Furthermore, activation of both cAMP and Ca2+ signaling is required for activation of svh-2 expression 26484536

名称对应

Type IDs
Gene
UniProtKB-ID: SVH2_CAEEL
UniprotKB: H2KZU7
UniParc: UPI00004034B2, UPI000007574A, UPI0000079356
EMBL: BX284606, AB693147
EnsemblGenome: WBGene00020504
KO: cel:CELE_T14E8.1
Nucleutide sequences
EMBL-CDS: CCD83400.1, BAL45942.1, CCD83401.1, CCD83402.1
Gene_ORFName: T14E8.1
EnsemblGenome_TRS: T14E8.1b.1, T14E8.1c.1, T14E8.1a.1, T14E8.1b.2
Protein sequencees
EnsemblGenome_PRO: T14E8.1a.1, T14E8.1b.2, T14E8.1b.1, T14E8.1c.1
RefSeq: NP_001368077.1, NP_001024906.1, NP_509104.1
Others
UniRef100: UniRef100_H2KZU7
UniRef90: UniRef90_H2KZU7
UniRef50: UniRef50_H2KZU7
UniGene: Cel.16854

全选

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