| Type | Description |
|---|---|
| Definition | Mechanosensory protein 2 |
| Date | Results | Publications |
|---|---|---|
| 2017-01-28 11:20:00 | Ubiquitin ligase Ubr4 is responsible for the degradation of mislocalized MEC-2 multimers. Ubiquitylation of one MEC-2 site, K301, do not only target MEC-2 for proteasomal degradation, but may also affect stability and disassembly of the multimeric complex. | 26792178 |
| 2014-06-07 10:05:00 | the carboxyl terminus of podocin/MEC-2 has to be placed at the inner leaflet of the plasma membrane to mediate cholesterol binding and contribute to ion channel activity. | 24596097 |
| 2012-12-08 10:09:00 | [review] Similarly to stomatins from other species, C. elegans counterparts may also be membrane proteins with intracellular amino- and carboxyl-terminals. | 21501885 |
| 2010-01-21 00:00:00 | MEC-2 with MEC-6 increase open probability of ENaC (constitutively active MEC-4/MEC-10 in Xenopus oocytes), decrease the efficiency of Ca2+ block. Its palmitoylation and cholesterol-binding activity are required for channel activation | 18504316 |
| 2010-01-21 00:00:00 | MEC-2, Podocin, and probably many other PHB-domain proteins by binding to themselves, cholesterol, and target proteins regulate the formation and function of large protein-cholesterol supercomplexes in the plasma membrane | 17079490 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
MEC2_CAEEL,
H2KZ92_CAEEL,
Q8MQ74_CAEEL
UniprotKB:
Q27433,
H2KZ92,
Q8MQ74
UniParc:
UPI000044F58D,
UPI000012EEA4,
UPI0000074EF4
EMBL:
FO080820,
U26735,
BX284606,
U26736
EnsemblGenome:
WBGene00003166
|
| Nucleutide sequences |
EMBL-CDS:
AAA87551.1,
AAA87552.1,
CCD83468.1,
CCD83470.1,
CCD83469.1
Gene_ORFName:
F14D12.4,
F14D12.4,
CELE_F14D12.4,
CELE_F14D12.4,
F14D12.4
EnsemblGenome_TRS:
F14D12.4a.1
|
| Protein sequencees |
EnsemblGenome_PRO:
F14D12.4a.1
RefSeq:
NP_001368717.1,
NP_001368712.1,
NP_001355480.1,
NP_001368713.1,
NP_741797.1,
NP_001368710.1,
NP_001355479.1,
NP_001355458.1,
NP_001368715.1,
NP_001355478.1,
NP_001355460.1,
NP_001368714.1,
NP_001024567.1,
NP_001368716.1,
NP_001024566.1,
NP_001355459.1,
NP_001355457.1
|
| Others |
UniRef100:
UniRef100_Q27433,
UniRef100_Q8MQ74,
UniRef100_H2KZ92
UniRef90:
UniRef90_Q27433,
UniRef90_H2KZ92,
UniRef90_Q8MQ74
UniRef50:
UniRef50_Q8MQ74,
UniRef50_Q21190,
UniRef50_Q27433
UniGene:
Cel.7750
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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