| Type | Description |
|---|---|
| Definition | Suppressor of presenilin protein 3 |
| Date | Results | Publications |
|---|---|---|
| 2020-03-28 11:24:00 | In wild-type worms, overexpression of spr-4 suppresses excitation and extends lifespan. REST, SPR-3, SPR-4 and reduced excitation activate the longevity-associated transcription factors FOXO1 and DAF-16 in mammals and worms, respectively. These findings reveal a conserved mechanism of ageing that is mediated by neural circuit activity and regulated by REST. | 31619788 |
| 2010-01-21 00:00:00 | Data report the cloning and characterization of spr-3 and spr-4, which encode large basic zinc-finger proteins which act as transcriptional repressors for sel-12 [spr-3 and spr-4]. | 12668626 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
SPR3_CAEEL
UniprotKB:
Q17768
UniParc:
UPI00002282B1,
UPI00001BDCAC
EMBL:
FO080373
EnsemblGenome:
WBGene00005008
KO:
cel:CELE_C07A12.5
|
| Nucleutide sequences |
EMBL-CDS:
CCD63278.1,
CCD63279.1
Gene_ORFName:
C07A12.5
EnsemblGenome_TRS:
C07A12.5b.1,
C07A12.5a.1
|
| Protein sequencees |
EnsemblGenome_PRO:
C07A12.5a.1,
C07A12.5b.1
RefSeq:
NP_001359833.1,
NP_001024367.1
|
| Others |
UniRef100:
UniRef100_Q17768
UniRef90:
UniRef90_Q17768
UniRef50:
UniRef50_Q17768
UniGene:
Cel.24627
|
| 排名 | 科研单位 | 文献 |
|---|---|---|
| 1 |
Department of Genetics, Harvard Medical School, Boston, MA, USA. |
1 |
| 2 |
The University of Texas McGovern Medical School |
1 |
| 3 |
The University of Texas MD Anderson Cancer Center |
1 |
| 4 |
Department of Genetics, Harvard Medical School, Boston, MA, USA. bruce_yankner@hms.harvard.edu. |
1 |
| 5 |
Rush University Medical Center |
1 |
| 排名 | 研究人员 | 文献 |
|---|---|---|
| 1 |
Noah Davidsohn |
1 |
| 2 |
George M Church |
1 |
| 3 |
Joseph M Zullo |
1 |
| 4 |
Sameer C Dhamne |
1 |
| 5 |
Monica P Colaiácovo |
1 |