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180722 spr-3

180722

spr-3

Suppressor of presenilin protein 3

protein-coding

Caenorhabditis elegans

基因描述

Type Description
Definition Suppressor of presenilin protein 3

研究结论

Date Results Publications
2020-03-28 11:24:00 In wild-type worms, overexpression of spr-4 suppresses excitation and extends lifespan. REST, SPR-3, SPR-4 and reduced excitation activate the longevity-associated transcription factors FOXO1 and DAF-16 in mammals and worms, respectively. These findings reveal a conserved mechanism of ageing that is mediated by neural circuit activity and regulated by REST. 31619788
2010-01-21 00:00:00 Data report the cloning and characterization of spr-3 and spr-4, which encode large basic zinc-finger proteins which act as transcriptional repressors for sel-12 [spr-3 and spr-4]. 12668626

名称对应

Type IDs
Gene
UniProtKB-ID: SPR3_CAEEL
UniprotKB: Q17768
UniParc: UPI00002282B1, UPI00001BDCAC
EMBL: FO080373
EnsemblGenome: WBGene00005008
KO: cel:CELE_C07A12.5
Nucleutide sequences
EMBL-CDS: CCD63278.1, CCD63279.1
Gene_ORFName: C07A12.5
EnsemblGenome_TRS: C07A12.5b.1, C07A12.5a.1
Protein sequencees
EnsemblGenome_PRO: C07A12.5a.1, C07A12.5b.1
RefSeq: NP_001359833.1, NP_001024367.1
Others
UniRef100: UniRef100_Q17768
UniRef90: UniRef90_Q17768
UniRef50: UniRef50_Q17768
UniGene: Cel.24627

全选

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研究热度

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