| Type | Description |
|---|---|
| Definition | Vang-like protein |
| Date | Results | Publications |
|---|---|---|
| 2019-04-13 10:15:00 | This work reveals a novel mechanism mediated by the planar cell polarity protein VANG-1 that downregulates Wnt signaling through Frizzled endocytosis. | 30504124 |
| 2019-03-09 11:36:00 | The Vangl ortholog VANG-1 influences the Wnt signaling response of the Q neuroblasts by negatively regulating canonical Wnt signaling. This inhibitory activity depends on a carboxy-terminal PDZ binding motif in VANG-1 and the Dishevelled ortholog MIG-5, but is independent of the Pk ortholog PRKL-1. | 30532125 |
| 2018-07-21 11:18:00 | Loss of the Frizzled receptor LIN-17 or the planar cell polarity (PCP) protein VANG-1 also caused cross over defects that did not enhance those in the cam-1 mutant, indicating that the proteins function together in midline guidance.. Strong cam-1 expression can be detected in the PVQs and the guidepost cell PVT that is located on the midline | 28993416 |
| 2017-06-03 10:48:00 | We find that VANG-1 promotes Wnt signaling by facilitating Frizzled endocytosis and genetically acts in a common pathway with arr-1/beta-arrestin, whose mutation results in defective PLM branching and F-actin patterns similar to those in the Wnt, mig-1 or vang-1 mutants | 28384160 |
| 2012-08-04 10:23:00 | that two alleles of vang-1 and depletion of the protein by cause an increase of mean life span up to 40%. | 22359667 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
Q95ZZ6_CAEEL,
H2KY90_CAEEL
UniprotKB:
Q95ZZ6,
H2KY90
UniParc:
UPI000007F8C1,
UPI000007696D
EMBL:
BX284606
EnsemblGenome:
WBGene00015171
KO:
cel:CELE_B0410.2
|
| Nucleutide sequences |
EMBL-CDS:
CCD61853.1,
CCD61852.1
Gene_ORFName:
CELE_B0410.2,
B0410.2,
B0410.2,
CELE_B0410.2
|
| Protein sequencees |
RefSeq:
NP_508501.1,
NP_508500.1
|
| Others |
UniRef100:
UniRef100_Q95ZZ6,
UniRef100_H2KY90
UniRef90:
UniRef90_H2KY90
UniRef50:
UniRef50_H2KY90
UniGene:
Cel.22757
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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