Type | Description |
---|---|
Definition | Presenilin sel-12 |
Date | Results | Publications |
---|---|---|
2019-03-02 10:34:00 | Mutations in the C. elegans gene encoding a PSEN homolog, sel-12 result in mitochondrial metabolic defects that promote neurodegeneration as a result of oxidative stress. | 29989545 |
2016-09-17 10:12:00 | mutations in sel-12 result in defects in calcium homeostasis, leading to mitochondrial dysfunction | 26500256 |
2010-01-21 00:00:00 | Data report the cloning and characterization of spr-3 and spr-4, which encode large basic zinc-finger proteins which act as transcriptional repressors for sel-12 [spr-3 and spr-4]. | 12668626 |
2010-01-21 00:00:00 | A genetic null allele mutant, sel-12(ar171), showed resistance to oxidative stress and prevented mitochondrial dysfunction-induced apoptosis. | 12556527 |
2010-01-21 00:00:00 | spr-2 mutations do not suppress sel-12 by affecting nonsense mediated decay, and increase the levels of sel-12 transcripts with premature translation termination codons. | 19302704 |
Type | IDs |
---|---|
Gene |
UniProtKB-ID:
PSN_CAEEL
UniprotKB:
P52166
UniParc:
UPI00001327DF
EMBL:
AF171064,
BX284606,
U35660
EnsemblGenome:
WBGene00004769
KO:
cel:CELE_F35H12.3
|
Nucleutide sequences |
EMBL-CDS:
AAD50991.1,
AAA85511.1,
CCD70617.1
Gene_ORFName:
F35H12.3
EnsemblGenome_TRS:
F35H12.3.1
|
Protein sequencees |
EnsemblGenome_PRO:
F35H12.3.1
RefSeq:
NP_508175.1
|
Others |
UniRef100:
UniRef100_P52166
UniRef90:
UniRef90_P52166
UniRef50:
UniRef50_P52166
UniGene:
Cel.19557
|
排名 | 科研单位 | 文献 |
---|---|---|
1 |
Ludwig-Maximilians-Universitaet |
2 |
2 |
Howard Hughes Medical Institute |
2 |
3 |
Albany Medical College |
2 |
4 |
Princeton University |
1 |
5 |
The Wellcome Trust Sanger Institute |
1 |
排名 | 研究人员 | 文献 |
---|---|---|
1 |
I Greenwald |
4 |
2 |
D Levitan |
2 |
3 |
E J Hubbard |
2 |
4 |
G Wu |
2 |
5 |
Shaarika Sarasija |
2 |