| Type | Description |
|---|---|
| Definition | neurofilament, light polypeptide |
| Date | Results | Publications |
|---|---|---|
| 2021-03-20 13:25:00 | as a Potential Biomarker of Axonal Degeneration in Experimental Autoimmune Encephalomyelitis. | 32189712 |
| 2019-07-20 10:10:00 | Neurofilament light protein in CSF and blood is associated with neurodegeneration and disease severity in Huntington's disease R6/2 mice | 29074982 |
| 2019-03-09 10:49:00 | NFL deficits cause an N-methyl-D-aspartic acid receptor hypofunction phenotype including abnormal hippocampal function, as seen in schizophrenia. NFL-/- deletion in mice reduces dendritic spines and GluN1 protein levels, elevates ubiquitin-dependent turnover of GluN1 and hippocampal glutamate measured by MRS, and depresses hippocampal long-term potentiation. | 30143609 |
| 2017-12-09 12:18:00 | Study found that NFL protein levels are at least doubled in pmn mutant motoneurons and that NFL depletion rescues defective axon growth in cultured motoneurons and prolongs survival of pmn mutant mice. This effect was found both in Nefl+/-;pmn motoneurons in which elevated NF expression was brought back to wild-type control levels and in Nefl-/-;pmn motoneurons in which axonal neurofilament was completely lost. | 27021905 |
| 2016-06-11 10:18:00 | It may have a role in protecting neurites from dystrophy and in regulating cellular pathways related to the generation of Ab plaques. | 26344875 |
| Type | IDs |
|---|---|
| Synonymous | AI847934, CMT2E, NF-L, NF68, Nfl |
| Gene |
UniProtKB-ID:
NFL_MOUSE
UniprotKB:
P08551
UniParc:
UPI00000282E7
EMBL:
BC029203,
AH002053,
M20480,
X02165,
M13016,
DQ201635
Ensembl:
ENSMUSG00000022055
KO:
mmu:18039
|
| Nucleutide sequences |
EMBL-CDS:
ABA46748.1,
AAA39810.1,
AAH29203.1,
CAB51616.1,
AAA39812.1,
AAA39814.1
Ensembl_TRS:
ENSMUST00000022639
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000022639
RefSeq:
NP_035040.1
|
| Others |
UniRef100:
UniRef100_P08551
UniRef90:
UniRef90_P07196
UniRef50:
UniRef50_P07196
UniGene:
Mm.1956
CCDS:
CCDS27232.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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