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180357 pha-4

180357

pha-4

Defective pharyngeal development protein 4

protein-coding

Caenorhabditis elegans

基因描述

Type Description
Definition Defective pharyngeal development protein 4

研究结论

Date Results Publications
2017-05-13 12:38:00 Reduced signaling through the insulin-like receptor daf-2/InsR in the maternal soma causes constitutively large progeny, and its effector daf-16/FoxO is required for this effect. nhr-49/Hnf4, pha-4/FoxA, and skn-1/Nrf also regulate progeny-size plasticity. Genetic analysis suggests that insulin-like signaling controls progeny size in part through regulation of nhr-49/Hnf4, and that pha-4/FoxA and skn-1/Nrf function 27783623
2015-07-25 11:13:00 results suggest that PHA-4 employs feed-forward loops to fine-tune gene expression and instil robustness in the system during energy crisis. 25504288
2015-07-25 10:58:00 these results suggest that Pol II recruitment, in addition to chromatin opening, is an important feature of PHA-4 pioneer factor activity. 26089518
2015-06-20 10:25:00 A network analysis of aging-associated miRNAs connected to transcription factors PHA-4/FOXA and SKN-1/Nrf revealed extensive regulatory interactions between PHA-4, SKN-1, and miRNAs undergoing dietary restriction. 25242029
2013-08-31 10:16:00 Suppression of misfolding in muscle cells is achieved not only by enhanced expression of HSP90 in muscle cells but also by elevated expression of HSP90 (Daf-21) in intestine or neuronal cells. This cell-nonautonomous control of HSP90 expression relies upon transcriptional feedback between somatic tissues that is regulated by the FoxA transcription factor PHA-4. 23746847

名称对应

Type IDs
Gene
UniProtKB-ID: PHA4_CAEEL
UniprotKB: Q17381
UniParc: UPI0000D722CC, UPI0000D722CB, UPI0000083388
EMBL: BX284605, U51163
EnsemblGenome: WBGene00004013
KO: cel:CELE_F38A6.1
Nucleutide sequences
EMBL-CDS: CAK12560.1, AAA96319.1, CAK12559.1, CAB07378.1
Gene_ORFName: F38A6.1
EnsemblGenome_TRS: F38A6.1c.1, F38A6.1a.1, F38A6.1b.1
Protein sequencees
EnsemblGenome_PRO: F38A6.1a.1, F38A6.1c.1, F38A6.1b.1
RefSeq: NP_001041116.1, NP_001041115.1, NP_001041114.1
Others
UniRef100: UniRef100_Q17381
UniRef90: UniRef90_Q17381
UniRef50: UniRef50_Q17381
UniGene: Cel.17389

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