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180311 unc-51

180311

unc-51

Serine/threonine-protein kinase unc-51

protein-coding

Caenorhabditis elegans

基因描述

Type Description
Definition Serine/threonine-protein kinase unc-51

研究结论

Date Results Publications
2019-07-13 12:05:00 Using pharmacological and genetic approaches, we found that worms deficient for autophagy were short-lived during starvation and recovered poorly from extended starvation, indicating sensitivity to nutrient stress. Autophagy mutants unc-51/Atg1 and atg-18/Atg18 maintained greater mtDNA content than wild-type worms during starvation, suggesting that autophagy promotes mitochondrial degradation during starvation 30133321
2010-06-14 11:18:00 PP2A cooperates with UNC-51 to regulate axon guidance by regulating phosphorylation. 20392746
2010-01-21 00:00:00 Inactivation of unc-51, bec-1 and lgg-1, the worm counterparts of the yeast autophagy genes Atg1, Atg6 and Atg8 respectively, partially suppresses degeneration of neurons with toxic ion channel variants. 17327275
2010-01-21 00:00:00 Mutants with impaired growth cone functions, such as unc-51, often exhibit abnormal terminations and inappropriate trajectories at the distal ends of the M2 axons. 12885562
2010-01-21 00:00:00 VAB-8 and UNC-14 are substrates that mediate the function of UNC-51 in axon outgrowth 15539493

名称对应

Type IDs
Gene
UniProtKB-ID: UNC51_CAEEL
UniprotKB: Q23023
UniParc: UPI0000137C51
EMBL: Z38016, BX284605
EnsemblGenome: WBGene00006786
KO: cel:CELE_Y60A3A.1
Nucleutide sequences
EMBL-CDS: CAA86114.1, CAB60406.1
Gene_ORFName: Y60A3A.1
EnsemblGenome_TRS: Y60A3A.1.1
Protein sequencees
EnsemblGenome_PRO: Y60A3A.1.1
RefSeq: NP_507869.1
Others
UniRef100: UniRef100_Q23023
UniRef90: UniRef90_Q23023
UniRef50: UniRef50_Q23023
UniGene: Cel.5550

全选

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研究热度

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