| Type | Description |
|---|---|
| Definition | neurofibromin 2 |
| Date | Results | Publications |
|---|---|---|
| 2021-02-20 13:29:00 | Combined deletion of Bap1, Nf2, and Cdkn2ab causes rapid onset of malignant mesothelioma in mice. | 32271879 |
| 2020-07-04 11:26:00 | identified a previously unreported Merlin-binding protein, apoptosis-stimulated p53 protein 2 (ASPP2, also called Tp53bp2), that bound to closed-conformation Merlin predominately through the FERM domain. | 31015291 |
| 2020-06-20 12:49:00 | NF2 role in the development of pleural malignant mesothelioma. | 31151962 |
| 2020-03-14 10:09:00 | a functional link between the Na,K-ATPase beta2-subunit and Merlin/NF2 and suggest a role for the beta2-subunit in regulating cytoskeletal dynamics and Hippo/YAP signaling during neuronal differentiation, is reported. | 31062247 |
| 2018-11-24 12:13:00 | Results demonstrate that loss of merlin function in Schwann Cells (SCs) leads to increased endoneurial space and ultrastructural myelin alterations in the sciatic nerve before and after injury. Loss of merlin function in SCs delays neural recovery following injury. Nevertheless, there were no significant functional or electrophysiological differences in neural regeneration attributable to Nf2 mutation in SCs. | 29408605 |
| Type | IDs |
|---|---|
| Synonymous | merlin |
| Gene |
UniProtKB-ID:
MERL_MOUSE,
Q9D3K3_MOUSE,
Q3TIW4_MOUSE
UniprotKB:
P46662,
Q9D3K3,
Q3TIW4
UniParc:
UPI00005B23A8,
UPI00000EAEA4,
UPI00000E71C1,
UPI000016D02E
EMBL:
X75759,
X74671,
AK017343,
AK167685,
L28176,
AK045998,
L27090,
L27105
Ensembl:
ENSMUSG00000009073
KO:
mmu:18016
|
| Nucleutide sequences |
EMBL-CDS:
AAA39807.1,
CAA53386.1,
BAC32567.1,
CAA52737.1,
AAA39808.1,
AAA63648.1,
BAB30698.1,
BAE39732.1
Ensembl_TRS:
ENSMUST00000053079,
ENSMUST00000109910,
ENSMUST00000056290
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000055061,
ENSMUSP00000105536,
ENSMUSP00000055033
RefSeq:
XP_036012295.1,
NP_001239182.1,
NP_001239179.1,
NP_001348605.1,
XP_006514633.1,
NP_001348604.1,
XP_011241971.1,
NP_035028.2,
NP_001239180.1,
XP_036012294.1,
XP_030101505.1,
NP_001239181.1,
NP_001348606.1
|
| Others |
UniRef100:
UniRef100_Q9D3K3,
UniRef100_P46662
UniRef90:
UniRef90_P46662
UniRef50:
UniRef50_P35240-2
UniGene:
Mm.297109
CCDS:
CCDS56757.1,
CCDS24391.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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