| Type | Description |
|---|---|
| Definition | Norrie disease (pseudoglioma) (human) |
| Date | Results | Publications |
|---|---|---|
| 2019-09-28 12:57:00 | In the developmental retinal vascular pathology present in the Ndph-knockout mouse inflammatory processes are active. | 29654250 |
| 2019-07-20 10:53:00 | Norrin protects optic nerve axons from degeneration in a mouse model of glaucoma | 29079753 |
| 2019-05-25 12:11:00 | Study shows that astrocytic Norrin appears to regulate dendrites and spines. Astroglia are enriched in mouse cortical layer V; express Norrin and leucine-rich repeat-containing G-protein-coupled receptor 6, are found in the human cortex; and modulate neuronal activity. | 30936556 |
| 2019-02-16 11:41:00 | High amounts of TGF-beta in the eye cause a substantial reduction in the activity of Wnt/beta-catenin signaling. This effect is inhibited in the presence of high amounts of Norrin, which further induce the expression of SMAD7 to inhibit TGF-beta signaling. | 29715368 |
| 2019-02-09 10:32:00 | experiments define the extent of CNS region-specific cooperation for several components of the Norrin and Wnt7a/Wnt7b systems, and they reveal substantial regional heterogeneity in the extent to which partially redundant ligands, receptors, and coactivators maintain the blood-brain barrier and blood-retina barrier | 30478038 |
| Type | IDs |
|---|---|
| Synonymous | ND, Ndph |
| Gene |
UniProtKB-ID:
NDP_MOUSE
UniprotKB:
P48744
UniParc:
UPI0000024D31
EMBL:
BC090623,
AL732321,
X83794,
X92397
Ensembl:
ENSMUSG00000040138
KO:
mmu:17986
|
| Nucleutide sequences |
EMBL-CDS:
AAH90623.1,
CAA63134.1,
CAA58725.1
Ensembl_TRS:
ENSMUST00000040134
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000046692
RefSeq:
NP_035013.1
|
| Others |
UniRef100:
UniRef100_P48744
UniRef90:
UniRef90_P48744
UniRef50:
UniRef50_Q00604
UniGene:
Mm.5014
CCDS:
CCDS30034.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员