| Type | Description |
|---|---|
| Definition | Alpha-catenin-like protein hmp-1 |
| Date | Results | Publications |
|---|---|---|
| 2018-05-26 10:04:00 | data indicate that HMP-1 does not modulate HMR-1/E-cadherin turnover, is required to recruit junctional actin but not stress fiber-like actin bundles. | 29466456 |
| 2017-10-14 13:05:00 | Deletion analysis based on the crystal structure shows that the first helix of HMP-1 is necessary for binding HMP-2 avidly in vitro and for efficient recruitment of HMP-1 to adherens junctions in embryos. HMP-2 Ser-47 and Tyr-69 flank its binding interface with HMP-1, and we show that phosphomimetic mutations at these two sites decrease binding affinity of HMP-1 to HMP-2 by 40-100-fold | 28842483 |
| 2017-07-15 11:54:00 | HMP-1 bound filamentous actin with an affinity in the single micromolar range, even when complexed with the beta-catenin homolog HMP-2 or when present in a complex of HMP-2 and the cadherin homolog HMR-1, indicating that HMP-1 binding to F-actin is not allosterically regulated by the HMP-2.HMR-1 complex. | 28298447 |
| 2013-04-27 11:19:00 | Specific conserved C-terminal amino acids of Caenorhabditis elegans HMP-1/alpha-catenin modulate F-actin binding independently of vinculin | 23271732 |
| 2013-01-12 10:02:00 | In vitro, UNC-94 acts in combination with HMP-1, leading to longer actin bundles than with HMP-1 alone. | 22771044 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
HMP1_CAEEL,
F5GUG3_CAEEL,
I7J4D2_CAEEL,
A5JYX3_CAEEL,
I7LFF2_CAEEL
UniprotKB:
P90947,
F5GUG3,
I7J4D2,
A5JYX3,
I7LFF2
UniParc:
UPI000209E198,
UPI0001529905,
UPI0000077DB1,
UPI00026B972D,
UPI00026B972E
EMBL:
BX284605,
Z81579,
AF016852
EnsemblGenome:
WBGene00001978
KO:
cel:CELE_R13H4.4
|
| Nucleutide sequences |
EMBL-CDS:
CAB61019.1,
AAB94551.1,
CCA65605.1,
CCJ09421.1,
CAN86617.1,
CCJ09420.1
Gene_ORFName:
R13H4.4,
CELE_R13H4.4,
R13H4.4,
R13H4.4,
CELE_R13H4.4,
R13H4.4,
CELE_R13H4.4,
R13H4.4,
CELE_R13H4.4
EnsemblGenome_TRS:
R13H4.4a.1
|
| Protein sequencees |
EnsemblGenome_PRO:
R13H4.4a.1
RefSeq:
NP_001256379.1,
NP_001122991.1,
NP_001370891.1,
NP_001360176.1,
NP_001263866.1,
NP_505985.1
|
| Others |
UniRef100:
UniRef100_I7LFF2,
UniRef100_P90947,
UniRef100_I7J4D2,
UniRef100_A5JYX3
UniRef90:
UniRef90_P90947
UniRef50:
UniRef50_P90947
UniGene:
Cel.22869
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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