| Type | Description |
|---|---|
| Definition | myocilin |
| Date | Results | Publications |
|---|---|---|
| 2020-10-24 14:07:00 | MEF2c-Dependent Downregulation of Myocilin Mediates Cancer-Induced Muscle Wasting and Associates with Cachexia in Patients with Cancer. | 32132110 |
| 2020-01-18 11:17:00 | Phenotypic differences observed in mouse and human studies of mutant myocilin could be a function of aggregation kinetics rates, which would alter the lifetime of putatively toxic protofibrillar intermediates. | 30802039 |
| 2019-04-27 10:21:00 | For this study, we utilized a transgenic mouse expressing human mutant MYOC Y437H protein and we examined its skeletal (gastrocnemius) muscle phenotype. Electron micrographs showed that sarcomeres in the skeletal muscle of mutant CMV-MYOC-Y437H mice had multiple M-bands. | 30395621 |
| 2019-04-13 10:07:00 | chaperone alphaB-crystallin (CRYAB) is a MYOC-binding partner and that co-expression of these two proteins increases protein aggregates. | 30389787 |
| 2017-05-27 11:31:00 | mutant myocilin induces abnormal ECM accumulation in the ER of TM cells, which may be responsible for reduced outflow facility and IOP elevation in myocilin-associated glaucoma. | 27820874 |
| Type | IDs |
|---|---|
| Synonymous | AI957332, GLC1A, TIGR |
| Gene |
UniProtKB-ID:
MYOC_MOUSE,
Q05AC1_MOUSE
UniprotKB:
O70624,
Q05AC1
UniParc:
UPI00000229A3
EMBL:
AF041335,
BC125329,
AF039869,
AF049796,
AF049794,
AF041334,
AF049795,
AB013592,
BC137606,
AF041333
Ensembl:
ENSMUSG00000026697
KO:
mmu:17926
|
| Nucleutide sequences |
EMBL-CDS:
AAC32805.1,
BAA32031.1,
AAC14265.1,
AAC40112.1,
AAI37607.1,
AAI25330.1
Ensembl_TRS:
ENSMUST00000028020
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000028020
RefSeq:
NP_034995.3
|
| Others |
UniRef100:
UniRef100_O70624
UniRef90:
UniRef90_O70624
UniRef50:
UniRef50_Q99972
UniGene:
Mm.10694
CCDS:
CCDS15422.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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