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179246 atg-18

179246

atg-18

AuTophaGy (yeast Atg homolog)

protein-coding

Caenorhabditis elegans

基因描述

Type Description
Definition AuTophaGy (yeast Atg homolog)

研究结论

Date Results Publications
2019-12-14 10:51:00 in the absence of either ATG-18 or EPG-6 autophagy was impaired, and while atg-18 mutant animals showed a short-lived phenotype, lifespan was significantly increased in epg-6 mutant animals. 30871075
2019-07-13 12:05:00 Using pharmacological and genetic approaches, we found that worms deficient for autophagy were short-lived during starvation and recovered poorly from extended starvation, indicating sensitivity to nutrient stress. Autophagy mutants unc-51/Atg1 and atg-18/Atg18 maintained greater mtDNA content than wild-type worms during starvation, suggesting that autophagy promotes mitochondrial degradation during starvation 30133321
2017-07-01 10:10:00 ATG-18 acts cell non-autonomously in neuronal and intestinal tissues to maintain C. elegans wildtype lifespan and to respond to DR and IGF-mediated longevity signaling. 28557996
2012-06-09 11:23:00 The autophagy proteins ATG-18 was sequentially recruited to internalized apoptotic Q cells in the phagocyte. 22451698

名称对应

Type IDs
Gene
UniProtKB-ID: ATG18_CAEEL
UniprotKB: O16466
UniParc: UPI000007EC9F, UPI000007F606
EMBL: BX284605
EnsemblGenome: WBGene00018294
KO: cel:CELE_F41E6.13
Nucleutide sequences
EMBL-CDS: CCD64090.1, CCD64091.1
Gene_ORFName: F41E6.13
EnsemblGenome_TRS: F41E6.13b.1, F41E6.13a.1
Protein sequencees
EnsemblGenome_PRO: F41E6.13b.1, F41E6.13a.1
RefSeq: NP_741576.1, NP_741577.1
Others
UniRef100: UniRef100_O16466
UniRef90: UniRef90_O16466
UniRef50: UniRef50_O16466
UniGene: Cel.17812

全选

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研究热度

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