| Type | Description |
|---|---|
| Definition | myosin VB |
| Date | Results | Publications |
|---|---|---|
| 2020-06-20 12:13:00 | Myo5b defects result in A stimulation that activates residual channels on the surface when intestinal epithelia are exposed to glucocorticoids at birth. | 31664880 |
| 2020-05-16 11:26:00 | The results suggest that apical bulk endocytosis in Myo5b KO enterocytes resembles activity-dependent bulk endocytosis, the primary mechanism for synaptic vesicle uptake during intense neuronal stimulation. | 31562230 |
| 2020-02-15 11:14:00 | Authors identified a novel role for MYO5B in the regulation of late endosome size control and identify the inability to control late endosome size as an unexpected novel mechanism underlying defects in cell division orientation and epithelial architecture. | 31682603 |
| 2017-11-25 15:28:00 | Data suggest that single-headed myosin-5B is intermediate-duty ratio motor with kinetic ATPase cycle, rate-limited by phosphate release; in transition to high-duty ratio motor, second head generates strain/gating in myosin-5B dimer that alter kinetic signature by slowing actin-activated ADP release to become rate-limiting; myosin-5B mutations cause microvillus inclusion disease and impact myosin motor function. | 28882893 |
| 2016-07-02 11:14:00 | Myo5b knockout mice closely resemble the phenotype of MVID patients and constitute a useful model to further investigate the underlying molecular mechanism of mirovillus inclusion disease. | 26201991 |
| Type | IDs |
|---|---|
| Synonymous | AI661750, mKIAA1119 |
| Gene |
UniProtKB-ID:
G5E8G6_MOUSE
UniprotKB:
G5E8G6
UniParc:
UPI00002160ED
EMBL:
AC148001,
AC148002,
AC147992
Ensembl:
ENSMUSG00000025885
KO:
mmu:17919
|
| Nucleutide sequences |
Ensembl_TRS:
ENSMUST00000074157
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000073790
RefSeq:
XP_006525779.1,
NP_963894.1,
XP_006525777.1,
XP_006525778.1,
XP_036016917.1
|
| Others |
UniRef100:
UniRef100_G5E8G6
UniRef90:
UniRef90_P21271
UniRef50:
UniRef50_Q9ULV0
UniGene:
Mm.260098
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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