| Type | Description |
|---|---|
| Definition | nudix (nucleoside diphosphate linked moiety X)-type motif 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-03-06 13:29:00 | Radiolabeled 6-(2, 3-Dichlorophenyl)-N4-methylpyrimidine-2, 4-diamine (TH287): A Potential Radiotracer for Measuring and Imaging MTH1. | 33238630 |
| 2021-01-16 16:00:00 | Role of As3mt and Mth1 in the genotoxic and carcinogenic effects induced by long-term exposures to arsenic in MEF cells. | 33141059 |
| 2018-11-17 11:57:00 | Increased cytotoxicity following MTH1 knockout or treatment with MTH1 inhibitor suggests the oxidation of precursor nucleotides. | 28067232 |
| 2018-06-02 10:44:00 | The crystal structures of mouse MTH1 in complex with inhibitor TH588 and dog MTH1 elucidate the structural and sequence basis for the observed difference in their affinities for TH588. Amino acid residue 116 in MTH1 is an important determinant of TH588 affinity. The structure of mouse MTH1 in complex with the substrate 8-oxo-dGTP is presented. | 29281266 |
| 2012-02-04 10:05:00 | These results suggest that MTH1 deficiency might be a causative factor for aging and age-related disorders. | 21538080 |
| Type | IDs |
|---|---|
| Synonymous | Mth1 |
| Gene |
UniProtKB-ID:
8ODP_MOUSE
UniprotKB:
P53368
UniParc:
UPI0000003EF3
EMBL:
AK088309,
BC098239,
CH466529,
D88356,
AK011695,
D49956,
BC021940,
AK168312
Ensembl:
ENSMUSG00000036639
KO:
mmu:17766
|
| Nucleutide sequences |
EMBL-CDS:
AAH21940.1,
AAH98239.1,
BAB27785.1,
BAE40252.1,
EDL19122.1,
EDL19123.1,
BAA19866.1,
BAA08711.1,
BAC40274.1
Ensembl_TRS:
ENSMUST00000050205,
ENSMUST00000071881,
ENSMUST00000110827,
ENSMUST00000110826
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000059983,
ENSMUSP00000106451,
ENSMUSP00000106450,
ENSMUSP00000071778
RefSeq:
NP_001343512.1,
NP_032663.1,
XP_006504718.1,
NP_001343514.1,
NP_001343513.1
|
| Others |
UniRef100:
UniRef100_P53368
UniRef90:
UniRef90_P53368
UniRef50:
UniRef50_P53368
UniGene:
Mm.118846
CCDS:
CCDS19818.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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