| Type | Description |
|---|---|
| Definition | Voltage-dependent L-type calcium channel subunit alpha |
| Date | Results | Publications |
|---|---|---|
| 2020-03-07 11:52:00 | Results identify two egl-19 gain-of-function mutations that are equivalent to the Timothy syndrome G402R and G406R mutations causing overextension of the PLM axon, leading to the misplacement of electrical synapses. Moreover, egl-19 gain-of-function mutations interact genetically with a homolog of the autism-associated WDFY3 selective autophagy gene to disrupt axon development and alter behavior. | 31805042 |
| 2018-02-17 10:09:00 | Here the authors show that the Caenorhabditis elegans SHN-1/Shank binds L-type calcium channels and that increased and decreased shn-1 gene dosage alter L-channel current and activity-induced expression of a CRH-1/CREB transcriptional target (gem-4 Copine). | 28477407 |
| 2016-05-14 11:49:00 | SLO-1 and SLO-2 localize close to UNC-2 and EGL-19 in AWC, suggesting a role of possible functional coupling between SLO BK channels and voltage-activated calcium channels in AWC asymmetry. | 26771544 |
| 2015-07-04 12:19:00 | Hyperactivation of L-type voltage-gated Ca2+ channels in Caenorhabditis elegans striated muscle can result from point mutations in the IS6 or the IIIS4 segment of the alpha1 subunit. | 25214488 |
| 2011-12-10 11:19:00 | EGL-19, UNC-36, and CCB-1 underlie voltage-dependent calcium currents in C. elegans striated muscle. | 21878625 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
G5EG02_CAEEL,
Q8MQA1_CAEEL
UniprotKB:
G5EG02,
Q8MQA1
UniParc:
UPI000007CC59,
UPI000007AD0E
EMBL:
BX284604,
AF023602
EnsemblGenome:
WBGene00001187
KO:
cel:CELE_C48A7.1
|
| Nucleutide sequences |
EMBL-CDS:
AAC47755.1,
CCD62065.1,
CCD62066.1
Gene_ORFName:
C48A7.1,
CELE_C48A7.1,
C48A7.1,
CELE_C48A7.1
|
| Protein sequencees |
RefSeq:
NP_741442.1,
NP_001368449.1,
NP_001023079.1
|
| Others |
UniRef100:
UniRef100_G5EG02,
UniRef100_Q8MQA1
UniRef90:
UniRef90_Q8MQA1
UniRef50:
UniRef50_Q8MQA1
UniGene:
Cel.18210
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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