| Type | Description |
|---|---|
| Definition | deoxyribonuclease 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-10-31 13:18:00 | Evaluation of the functional effects of genetic variantsmissense and nonsense SNPs, indels and copy number variationsin the gene encoding human deoxyribonuclease I potentially implicated in autoimmunity. | 31541133 |
| 2019-09-14 11:36:00 | Human deoxyribonuclease I (DNaseI) is overexpressed and encapsidated in hepatitis B virus (HBV) particles in vitro in hypoxic environments and in vivo in cirrhotic patient livers as well as in the serum of infected patients. DNase I induces genome-free hepatitis B virions and is incorporated into hepatitis B viral capsids. A hypoxic environment enhances DNASE1 and restricts HBV. | 30936483 |
| 2019-07-20 12:35:00 | Cigarette smoke significantly increases the expression of neutrophil and macrophage extracellular traps with coexpression of the pathogenic proteases, neutrophil elastase and matrix metalloproteinases 9 and 12. This response to cigarette smoke was significantly reduced by the addition of DNase 1, which also significantly decreased macrophage numbers and lung proteolysis. | 28935869 |
| 2019-03-02 10:50:00 | EndoG is an endonuclease with the unique ability to inactivate another endonuclease, DNase I, and to modulate the development of apoptosis. | 30521874 |
| 2018-03-03 11:56:00 | Genetic variants in DNase I hypersensitive sites play an important role in carcinogenesis. two novel single nucleotide polymorphisms rs12309362 (odds ratio = 0.64, P = 5.61 x 10(-6) ) and rs9970827 (odds ratio = 0.73, P = 7.23 x 10(-6) ) significantly associated with decreased risk of HCC. | 28321907 |
| Type | IDs |
|---|---|
| Synonymous | DNL1, DRNI |
| Gene |
UniProtKB-ID:
DNAS1_HUMAN
UniprotKB:
P24855
UniParc:
UPI00017A7DC3,
UPI0000043698
EMBL:
AK300914,
AJ298844,
AC005203,
M55983,
AB188151,
CH471112,
D83195,
AC006111,
BC029437,
AB188152
Ensembl:
ENSG00000213918
KO:
hsa:1773
|
| Nucleutide sequences |
EMBL-CDS:
EAW85344.1,
BAA11841.1,
AAA63170.1,
AAH29437.1,
BAE96964.1,
CAC12813.1,
AAC24721.1,
BAG62547.1,
BAE96965.1
Ensembl_TRS:
ENST00000407479,
ENST00000246949
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000246949,
ENSP00000385905
RefSeq:
NP_001374068.1,
NP_001338754.1,
XP_024305940.1,
XP_016878482.1,
XP_016878489.1,
NP_001374064.1,
NP_001374070.1,
XP_006720917.1,
NP_005214.2,
NP_001374069.1,
XP_016878490.1,
XP_024305937.1,
XP_024305939.1,
XP_016878481.1,
XP_016878495.1,
XP_016878492.1,
XP_016878493.1,
XP_016878494.1,
XP_016878491.1,
XP_024305938.1
|
| Others |
UniRef100:
UniRef100_P24855
UniRef90:
UniRef90_P24855
UniRef50:
UniRef50_P24855
UniGene:
Hs.629638,
Hs.733045
CCDS:
CCDS10507.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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