| Type | Description |
|---|---|
| Definition | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase daf-18 |
| Date | Results | Publications |
|---|---|---|
| 2020-10-03 12:59:00 | The precursor of PI(3,4,5)P3 alleviates aging by activating daf-18(Pten) and independent of daf-16. | 32901024 |
| 2020-04-11 12:03:00 | The decision of somatic gonad blast cells (SGBs) and germline stem cells (GSCs) to be quiescent or progress developmentally is regulated differently from the non-gonadal soma: daf-18/PTEN acts non-autonomously within the somatic gonad to maintain developmental quiescence of both SGBs and GSCs. | 30827916 |
| 2019-04-13 10:14:00 | AMPK functions downstream of, or in parallel with DAF-18/PTEN and insulin/IGF-1 signaling to inhibit PP2A function. | 30487179 |
| 2017-06-03 11:27:00 | our results imply that DAF-18/PTEN, through PAR-4/LKB1, can activate AAK-1/AMPK in the absence of apparent energy stress. As all components are conserved, similar signalling cascades may regulate stem cell activities in other organisms and be widely implicated in cancer. | 28410423 |
| 2016-05-28 10:17:00 | differential regulation of germline stem cell proliferation rates in Caenorhabditis elegans adults is accomplished through localized neutralization of insulin/IGF-1 signalling, requiring DAF-18/PTEN. | 26552888 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
PTEN_CAEEL
UniprotKB:
G5EE01
UniParc:
UPI000008017A
EMBL:
BX284604,
AF098286,
AJ131181,
AF126286
EnsemblGenome:
WBGene00000913
KO:
cel:CELE_T07A9.6
|
| Nucleutide sequences |
EMBL-CDS:
AAD21620.1,
CCD73977.1,
CAA10315.1,
AAD03420.1
Gene_ORFName:
T07A9.6
EnsemblGenome_TRS:
T07A9.6.1
|
| Protein sequencees |
EnsemblGenome_PRO:
T07A9.6.1
RefSeq:
NP_499926.1
|
| Others |
UniRef100:
UniRef100_G5EE01
UniRef90:
UniRef90_G5EE01
UniRef50:
UniRef50_G5EE01
UniGene:
Cel.38708
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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