| Type | Description |
|---|---|
| Definition | mutS homolog 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-01-18 10:21:00 | An average 388-fold increase in mutation per mitosis rate was observed in Msh2-deficient intestinal crypts compared to wild-type epithelium. | 31126976 |
| 2018-04-28 11:39:00 | Msh2 deficiency causes dysmyelination of the axonal projections in the corpus callosum. Evoked action potentials in the myelinated corpus callosum projections of Msh2-null mice were smaller than wild-type mice, whereas unmyelinated axons showed no difference. | 27476972 |
| 2017-09-30 13:36:00 | Deletion of the MSH2 C-terminus severely affected the stability of the MSH2/MSH6 heterodimer and consequently strongly attenuated DNA mismatch repair. The C-terminal truncation MSH2 mutant predisposed mice to tumor formation.Mutations deleting the MSH2 C-terminus can therefore unambiguously be considered as pathogenic and a cause of Lynch syndrome. | 27873144 |
| 2017-09-09 10:05:00 | Normal Msh2-deficient organoids showed increased inheritable transient cyst-like growth, which became independent of R-spondin. intestinal stem cell (ISC) proceeded faster in vitro than in vivo independent of the underlying genotype but more under Mutations in mismatch repair deficiency. | 27941880 |
| 2017-09-02 11:55:00 | Study shows that MSH2-/- mice develop spontaneous thymic lymphomas. | 28767666 |
| Type | IDs |
|---|---|
| Synonymous | AI788990 |
| Gene |
UniProtKB-ID:
MSH2_MOUSE,
Q3TZI5_MOUSE
UniprotKB:
P43247,
Q3TZI5
UniParc:
UPI000000BB63
EMBL:
BC047117,
X81143,
U21011,
AK157842
Ensembl:
ENSMUSG00000024151
KO:
mmu:17685
|
| Nucleutide sequences |
EMBL-CDS:
CAA57049.1,
AAA75027.1,
AAH47117.1,
BAE34223.1
Ensembl_TRS:
ENSMUST00000024967
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000024967
RefSeq:
NP_032654.1
|
| Others |
UniRef100:
UniRef100_P43247
UniRef90:
UniRef90_P43246
UniRef50:
UniRef50_P43246
UniGene:
Mm.4619
CCDS:
CCDS29019.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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