| Type | Description |
|---|---|
| Definition | DNA replication helicase/nuclease 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-08-01 12:01:00 | Study revealed that phosphorylated CtIP (pCtIP) dramatically stimulates the motor activity of DNA2. This accelerates degradation of RPA-coated ssDNA by DNA2, showing the need for the motor activity of DNA2 to facilitate resection. CtIP is thus a cofactor not only of MRE11, but also of DNA2, and domains of CtIP required for the stimulation of MRE11-RAD50-NBS1 (MRN) complex and DNA2 are physically separate. | 32241893 |
| 2020-03-21 11:20:00 | Multiple roles of DNA2 nuclease/helicase in DNA metabolism, genome stability and human diseases have been described. (Review) | 31754720 |
| 2019-12-14 11:30:00 | TNF receptor associated factor 6 (TRAF6)-mediated DNA replication helicase/nuclease 2 (hDNA2) ubiquitination activates DNA repair pathways to maintain nuclear genome integrity. | 31216032 |
| 2019-03-30 11:20:00 | Here, the authors show that DNA2 binds preferentially to centromeric DNA. The nuclease and helicase activities of DNA2 are both essential for resolution of DNA structural obstacles to facilitate DNA replication fork movement. | 29773570 |
| 2017-12-02 11:11:00 | This review mainly encompasses the key functions of DNA2 in human cells with various aspects, especially focusing on the genome integrity, and also generalizes the recent insights to the mechanisms related to the occurrence of cancer and other diseases potentially linked to the mutations in DNA2. | 28903076 |
| Type | IDs |
|---|---|
| Synonymous | DNA2L, hDNA2 |
| Gene |
UniProtKB-ID:
DNA2_HUMAN
UniprotKB:
P51530
UniParc:
UPI0000E8A8BA,
UPI000067DA82,
UPI00027DB79C,
UPI00001C1EDB
EMBL:
BC063664,
AL136233,
BC028188,
BC041115,
D42046,
BC111740,
BC053574
Ensembl:
ENSG00000138346
KO:
hsa:1763
|
| Nucleutide sequences |
EMBL-CDS:
AAH53574.1,
AAI11741.1,
AAH41115.1,
AAH63664.1,
BAA07647.1,
AAH28188.1
Ensembl_TRS:
ENST00000399179,
ENST00000358410,
ENST00000399180
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000382133,
ENSP00000351185,
ENSP00000382132
RefSeq:
XP_016871288.1,
NP_001073918.2,
XP_006717743.1,
XP_011537719.1
|
| Others |
UniRef100:
UniRef100_P51530
UniRef90:
UniRef90_P51530
UniRef50:
UniRef50_P51530
UniGene:
Hs.532446
CCDS:
CCDS44415.2
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员