| Type | Description |
|---|---|
| Definition | Histone-lysine N-methyltransferase met-2 |
| Date | Results | Publications |
|---|---|---|
| 2020-05-30 12:10:00 | Data show that the transgenerational aspects of wdr-5 mutant longevity require the H3K9me2 methyltransferase MET-2 (MET-2). | 31815663 |
| 2020-02-15 13:47:00 | Mutation of met-2 or lin-65 also disrupts the perinuclear anchoring of genomic heterochromatin. Loss of LIN-65, like that of MET-2, compromises temperature stress resistance and germline integrity, which are both linked to promiscuous repeat transcription and gene expression. | 30737265 |
| 2019-03-30 11:06:00 | Results find that SMRC-1 protects cells from DNA replication stress and promotes the accumulation of nuclear MET-2. Moreover, SMRC-1 affects MET-2 germline activity (as measured by histone modification state) in populations grown for multiple generations at stressful culture temperatures. Genetic analysis indicates that MET-2 and SMRC-1 participate in a common mechanism to limit DNA damage in the germ line. | 30794539 |
| 2018-05-19 11:54:00 | Authors discovered that MET-2 inhibits small RNA inheritance, and, as a consequence, induction of in met-2 mutants leads to permanent duanyu1615 responses that do not terminate even after more than 30 generations. | 28343968 |
| 2017-05-27 10:26:00 | both histone H3 lysine 9 di- and trimethylation were reduced in Cbr-met-2 mutant germ lines, suggesting that in contrast to C. elegans | 27280692 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
MET2_CAEEL
UniprotKB:
P34544
UniParc:
UPI0002998223
EMBL:
FO081667
EnsemblGenome:
WBGene00019883
KO:
cel:CELE_R05D3.11
|
| Nucleutide sequences |
EMBL-CDS:
CCD73198.2
Gene_ORFName:
R05D3.11
EnsemblGenome_TRS:
R05D3.11.1
|
| Protein sequencees |
EnsemblGenome_PRO:
R05D3.11.1
RefSeq:
NP_498848.4
|
| Others |
UniRef100:
UniRef100_P34544
UniRef90:
UniRef90_P34544
UniRef50:
UniRef50_P34544
UniGene:
Cel.5325
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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