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175739 paqr-2

175739

paqr-2

Progestin and AdipoQ Receptor family

protein-coding

Caenorhabditis elegans

基因描述

Type Description
Definition Progestin and AdipoQ Receptor family

研究结论

Date Results Publications
2020-05-16 11:37:00 We conclude that acs-13 mutations in C. elegans and ACSL1 knockdown in human cells prevent lipotoxicity by promoting increased levels of polyunsaturated fatty acid-containing phospholipids 31769755
2019-07-13 11:14:00 The Caenorhabditis elegans adiponectin receptor AdipoR2 homolog PAQR-2 signaling detects temperature drop and augments the biosynthesis of two omega-6 polyunsaturated fatty acids, gamma-linolenic acid and arachidonic acid. These two polyunsaturated fatty acids in turn initiate autophagy in the epidermis, delaying an age-dependent decline in collagen contents, and extending the lifespan. 31197136
2017-10-14 11:07:00 We conclude that the PAQR-2 and AdipoR2 proteins share an evolutionarily conserved function that maintains membrane fluidity in the presence of exogenous saturated fatty acids. 28886012
2016-08-20 10:15:00 PAQR-2 and IGLR-2 interact on plasma membranes and thus may act together as a fluidity sensor that controls membrane lipid composition. 27082444
2014-03-22 11:05:00 This model is supported by the observations that the paqr-2 suppressors normalize the levels of saturated fatty acids, and that low concentrations of detergents that increase membrane fluidity can rescue the paqr-2 mutant. 24068966

名称对应

Type IDs
Gene
UniProtKB-ID: Q9N536_CAEEL
UniprotKB: Q9N536
UniParc: UPI00001B29EF
EMBL: BX284603
EnsemblGenome: WBGene00021313
KO: cel:CELE_Y32H12A.5
Nucleutide sequences
EMBL-CDS: CCD73963.1
Gene_ORFName: Y32H12A.5, CELE_Y32H12A.5
Protein sequencees
RefSeq: NP_498148.2
Others
UniRef100: UniRef100_Q9N536
UniRef90: UniRef90_Q9N536
UniRef50: UniRef50_Q9N536
UniGene: Cel.17644

全选

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研究热度

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