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175662 set-2

175662

set-2

Histone-lysine N-methyltransferase set-2

protein-coding

Caenorhabditis elegans

基因描述

Type Description
Definition Histone-lysine N-methyltransferase set-2

研究结论

Date Results Publications
2017-12-30 10:34:00 Animals lacking SET-2 catalytic subunit show transgenerational increase in sensitivity to DNA damage-inducing agents that is accompanied by defect in DSB repair. These defects are not due to failure to activate the DNA damage response that allows detection, signaling and repair of DNA lesions, because cell cycle arrest and apoptosis, key components of this pathway, are efficiently induced in set2 mutants. 28779964
2011-07-30 11:05:00 SET-2 is responsible for the majority of bulk H3K4 methylation at all developmental stages 21527717
2010-01-21 00:00:00 These results suggest that HP1 and a SET1/MLL-related complex may play antagonistic roles in the epigenetic regulation of specific developmental programs. 17967446

名称对应

Type IDs
Gene
UniProtKB-ID: SET2_CAEEL
UniprotKB: Q18221
UniParc: UPI000007A0F6, UPI000007ACBC, UPI000007EC2F
EMBL: FO080680
EnsemblGenome: WBGene00004782
KO: cel:CELE_C26E6.9
Nucleutide sequences
EMBL-CDS: CCD65736.1, CCD65734.1, CCD65735.1
Gene_ORFName: C26E6.9
EnsemblGenome_TRS: C26E6.9c.1, C26E6.9a.1, C26E6.9b.1
Protein sequencees
EnsemblGenome_PRO: C26E6.9c.1, C26E6.9a.1, C26E6.9b.1
RefSeq: NP_498039.1, NP_498041.1, NP_498040.1
Others
UniRef100: UniRef100_Q18221
UniRef90: UniRef90_Q18221
UniRef50: UniRef50_Q18221
UniGene: Cel.8145

全选

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研究热度

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