| Type | Description |
|---|---|
| Definition | Insulin-like receptor subunit beta;Receptor protein-tyrosine kinase;hypothetical protein |
| Date | Results | Publications |
|---|---|---|
| 2019-11-09 12:21:00 | DAF-2 acts independently of the FOXO transcription factor, DAF-16, to mediate the protective effects of fasting. These results suggest a non-canonical role for the insulin/IGF-like signaling pathway in coordinating the effects of hypoxia and nutritional state on proteostasis. | 31246952 |
| 2019-05-25 10:59:00 | Daf-2 is required to regulate neuromuscular junction response to oxidative stress. Daf-2 functions downstream of Skn-1. | 30782598 |
| 2019-04-20 12:42:00 | DAF-2 and its downstream signaling molecules, including the DAF-16 FOXO transcription factor, act in the ascr#3-sensing ADL neurons to regulate synaptic transmission to downstream target neurons, including the AVA command interneurons. | 29925517 |
| 2019-03-23 11:06:00 | This study demonstrated that reducing daf-2, insulin/IGF signaling (IIS) prolongs life and ameliorates aspects of motor dysfunction in C. elegans models of Spinal Muscular Atrophy. | 30627660 |
| 2018-10-20 10:29:00 | our results indicate that Methyl 3,4-dihydroxybenzoate (MDHB) at least partially acts as a modulator of the daf-2/daf-16 pathway to extend the lifespan of C. elegans, and MDHB might be a promising therapeutic agent for age-related diseases | 29874838 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
INSR_CAEEL,
A0A0K3AUA1_CAEEL,
A0A0K3AXA0_CAEEL,
A0A0K3ARZ1_CAEEL,
A0A0K3ARE8_CAEEL,
A0A0K3AUY1_CAEEL
UniprotKB:
Q968Y9,
A0A0K3AUA1,
A0A0K3AXA0,
A0A0K3ARZ1,
A0A0K3ARE8,
A0A0K3AUY1
UniParc:
UPI00061794B0,
UPI0000482533,
UPI0005303F00,
UPI0005303EBD,
UPI0005303F1C,
UPI0005303F50
EMBL:
BX284603,
AF012437
EnsemblGenome:
WBGene00000898
KO:
cel:CELE_Y55D5A.5
|
| Nucleutide sequences |
EMBL-CDS:
AAC47715.1,
CCD72201.2,
CTQ86619.1,
CTQ86617.1,
CTQ86618.1,
CTQ86620.1,
CTQ86616.1
Gene_ORFName:
Y55D5A.5,
Y55D5A.5,
CELE_Y55D5A.5,
Y55D5A.5,
CELE_Y55D5A.5,
Y55D5A.5,
CELE_Y55D5A.5,
Y55D5A.5,
CELE_Y55D5A.5,
CELE_Y55D5A.5,
Y55D5A.5
EnsemblGenome_TRS:
Y55D5A.5a.2,
Y55D5A.5a.1
|
| Protein sequencees |
EnsemblGenome_PRO:
Y55D5A.5a.1,
Y55D5A.5a.2
RefSeq:
NP_001299920.1,
NP_001299916.1,
NP_001299918.1,
NP_001299917.1,
NP_497650.4,
NP_001299919.1
|
| Others |
UniRef100:
UniRef100_Q968Y9,
UniRef100_A0A0K3AUY1
UniRef90:
UniRef90_Q968Y9
UniRef50:
UniRef50_Q968Y9
UniGene:
Cel.8775
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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