| Type | Description |
|---|---|
| Definition | hypothetical protein |
| Date | Results | Publications |
|---|---|---|
| 2021-01-16 16:00:00 | Pathogenic Variants in the Myosin Chaperone UNC-45B Cause Progressive Myopathy with Eccentric Cores. | 33217308 |
| 2020-01-18 10:11:00 | Data highlight the importance of utilizing a flexible myosin-binding domain. This so-called UCS domain can adopt discrete conformations to efficiently bind and fold substrate. Moreover, our data uncover the molecular basis of temperature-sensitive UNC-45 mutations underlying one of the most prominent motility defects in C. elegans. | 31636255 |
| 2018-03-17 11:00:00 | UNC-45 chaperone can serve as an adaptor protein of UFD-2 to poly-ubiquitinate unfolded myosin, pointing to a possible role of the UFD-2/UNC-45 pair in maintaining proteostasis in muscle cells. | 29396393 |
| 2013-03-23 10:31:00 | Biochemical and structural analyses with in vivo studies of the C. elegans UNC-45 protein reveal a chaperone chain in which UNC-45 tandem modules assemble a multisite docking platform that enforces collaboration with Hsp70 and Hsp90 in a precisely defined pattern to assemble myosin filaments. | 23332754 |
| 2010-01-21 00:00:00 | UNC-45 is not required to fold or maintain the actin binding domain but is still required for myosin function. | 18190904 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
G5EG62_CAEEL
UniprotKB:
G5EG62
UniParc:
UPI0000077893
EMBL:
AF034085,
BX284603
EnsemblGenome:
WBGene00006781
KO:
cel:CELE_F30H5.1
|
| Nucleutide sequences |
EMBL-CDS:
CCD69153.1,
AAD01976.1
Gene_ORFName:
F30H5.1,
CELE_F30H5.1
|
| Protein sequencees |
RefSeq:
NP_497205.1
|
| Others |
UniRef100:
UniRef100_G5EG62
UniRef90:
UniRef90_G5EG62
UniRef50:
UniRef50_G5EG62
UniGene:
Cel.19943
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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