| Type | Description |
|---|---|
| Definition | myeloproliferative leukemia virus oncogene |
| Date | Results | Publications |
|---|---|---|
| 2020-10-31 13:19:00 | Signaling properties of murine MPL and MPL mutants after stimulation with thrombopoietin and romiplostim. | 32417303 |
| 2019-12-07 12:04:00 | Authors demonstrate that thrombopoietin and its receptor MPL are critical for the human JAK2V617F-bearing MK-induced myeloproliferation in mice, both by directly affecting the quantity and quality of MKs and by altering the MK-endothelial interaction and vascular niche function. | 30005133 |
| 2019-11-30 10:58:00 | These results indicate that c-MPL is a candidate LSC surface marker that may serve as a therapeutic target for the elimination of LSCs. | 30106501 |
| 2019-02-02 10:04:00 | these findings indicate that c-MPL deficiency is associated with abnormal maturation of neonatal megakaryocytes and developmental stage-specific defects in platelet function | 29212120 |
| 2017-08-05 12:41:00 | these results demonstrate that MPL P106L is a receptor with an incomplete defect in trafficking. | 28034873 |
| Type | IDs |
|---|---|
| Synonymous | CD110, TPO-R, c-mpl, hlb219 |
| Gene |
UniProtKB-ID:
TPOR_MOUSE,
A2A9D4_MOUSE
UniprotKB:
Q08351,
A2A9D4
UniParc:
UPI00001442F5,
UPI0000F4E55D,
UPI0000020F6C
EMBL:
BC146613,
Z22649,
AK041166,
Z22657,
X73677,
AL627212
Ensembl:
ENSMUSG00000006389
KO:
mmu:17480
|
| Nucleutide sequences |
EMBL-CDS:
CAA80365.1,
AAI46614.1,
BAC30846.1,
CAA52031.1,
CAA80372.1
Ensembl_TRS:
ENSMUST00000102671,
ENSMUST00000006556
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000099732,
ENSMUSP00000006556
RefSeq:
NP_034953.2,
NP_001272426.1,
NP_001116421.1,
NP_001272425.1,
XP_011238770.1
|
| Others |
UniRef100:
UniRef100_Q08351,
UniRef100_P40931
UniRef90:
UniRef90_Q08351
UniRef50:
UniRef50_P40238
UniGene:
Mm.4864
CCDS:
CCDS18552.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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