| Type | Description |
|---|---|
| Definition | multiple PDZ domain protein |
| Date | Results | Publications |
|---|---|---|
| 2019-08-10 11:22:00 | The authors show by magnetic resonance imaging that contrast medium penetrates into the brain ventricles of mice carrying a Mpdz loss-of-function mutation, whereas none is detected in the ventricles of normal mice, implying that the permeability of the choroid plexus epithelial cell monolayer is abnormally high. | 30518636 |
| 2019-07-27 10:57:00 | Tumor angiogenesis was enhanced upon endothelial-specific inactivation of MPDZ leading to an excessively branched and poorly functional vessel network resulting in tumor hypoxia through DLL4-induced Notch signaling. | 29620522 |
| 2018-03-17 11:11:00 | This work provides a relevant hydrocephalus mouse model and demonstrates that Mpdz is essential to maintain integrity of the ependyma. | 28500065 |
| 2016-11-12 10:29:00 | Variants of the multiple PDZ domain gene Mpdz may contribute to the observed inter-strain variability in opioid tolerance and opioid-induced hyperalgesia by virtue of changes in the level of their expression. | 27129385 |
| 2015-11-28 10:45:00 | MUPP1-PDZ4 domain contained three alpha-helices and six beta-strands in the core. The GLGI motif, L562/A564 on the beta-strand B, and H605/V608/L612 on the alpha-helix B formed a PDZ binding pocket which could bind to the C-terminal of the binding partners. | 25662616 |
| Type | IDs |
|---|---|
| Synonymous | AI225843, B930003D11Rik, MUPP1 |
| Gene |
UniProtKB-ID:
MPDZ_MOUSE,
Q3TUR5_MOUSE,
B2RQR2_MOUSE
UniprotKB:
Q8VBX6,
Q3TUR5,
B2RQR2
UniParc:
UPI00005B1C5D,
UPI000002879C,
UPI000052A465,
UPI00001F0F0D,
UPI000052A463,
UPI00017479BE
EMBL:
AF326528,
AL670939,
AK031321,
AF326534,
AF326536,
AF326538,
AK051782,
AF326529,
CR352325,
AF326539,
AF326544,
AF326526,
AF326531,
AF326540,
BC061504,
AF326533,
AF326541,
AF000168,
AF326532,
AF326542,
AF326535,
AF326543,
BC145117,
AF326530,
AF326537,
AF326527,
AJ131869,
BC138045,
AK160603
Ensembl:
ENSMUSG00000028402
KO:
mmu:17475
|
| Nucleutide sequences |
EMBL-CDS:
AAL37382.1,
AAL37375.1,
AAL37378.1,
AAL37390.1,
AAL37373.1,
BAC27346.1,
BAC34766.1,
CAA10523.1,
AAL37386.1,
AAL37380.1,
AAH61504.1,
AAL37388.1,
AAL37376.1,
AAL37389.1,
AAL37377.2,
AAI45118.1,
AAL37372.1,
AAL37381.1,
AAL37374.1,
AAL37387.1,
AAL37379.1,
AAL37385.1,
AAL37383.1,
AAB57835.1,
AAL37384.1,
BAE35906.1,
AAI38046.1
Ensembl_TRS:
ENSMUST00000102830,
ENSMUST00000107258,
ENSMUST00000220807
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000099894,
ENSMUSP00000102879,
ENSMUSP00000152533
RefSeq:
XP_006537707.1,
XP_036019684.1,
NP_001292215.1,
XP_006537713.1,
XP_006537712.1,
XP_036019686.1,
XP_011248242.1,
XP_036019687.1,
XP_006537709.1,
XP_036019688.1,
NP_001292213.1,
XP_036019682.1,
XP_006537710.1,
NP_034950.2,
XP_036019685.1,
XP_036019683.1,
XP_006537706.1,
XP_036019681.1
|
| Others |
UniRef100:
UniRef100_B2RQR2,
UniRef100_Q3TUR5,
UniRef100_Q8VBX6
UniRef90:
UniRef90_Q3TUR5,
UniRef90_Q8VBX6
UniRef50:
UniRef50_O75970,
UniRef50_Q3TUR5
UniGene:
Mm.153039
CCDS:
CCDS18292.1,
CCDS89767.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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