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174144 unc-104

174144

unc-104

Kinesin-like protein unc-104

protein-coding

Caenorhabditis elegans

基因描述

Type Description
Definition Kinesin-like protein unc-104

研究结论

Date Results Publications
2017-11-18 13:44:00 Synaptic vesicle bound small GTPase ARL-8 activates UNC-104 by unlocking the autoinhibition. The results demonstrate that the autoinhibitory mechanism is utilized to regulate the distribution of transport cargoes and is important for synaptogenesis in vivo. 27524618
2017-10-21 12:17:00 LIN-2 and SYD-2 both positively affect the velocity of UNC-104 27172328
2017-06-24 12:46:00 findings indicate that autophagy is spatially regulated in neurons through the transport of ATG-9 by KIF1A/UNC-104 to regulate neurodevelopment 27396362
2017-01-14 10:07:00 Reduced function of UNC-104 accelerates motor circuit dysfunction with age, whereas upregulation of UNC-104 significantly improves motor function at advanced ages and also mildly extends lifespan. In addition, UNC-104-overexpressing animals outperform wild-type controls in associative learning and memory tests. 26877087
2013-08-31 10:16:00 This study establishes an essential role of the CC1-FHA dimer for KIF1A/unc-104-mediated neuronal transport. 23669038

名称对应

Type IDs
Gene
UniProtKB-ID: UN104_CAEEL
UniprotKB: P23678
UniParc: UPI0002995CBB, UPI000016430C
EMBL: BX284602, M58582
EnsemblGenome: WBGene00006831
KO: cel:CELE_C52E12.2
Nucleutide sequences
EMBL-CDS: AAA03517.1, CCD64622.2, CCD64623.2
Gene_ORFName: C52E12.2
EnsemblGenome_TRS: C52E12.2a.1, C52E12.2b.1, C52E12.2b.2, C52E12.2a.2
Protein sequencees
EnsemblGenome_PRO: C52E12.2a.2, C52E12.2a.1, C52E12.2b.1, C52E12.2b.2
RefSeq: NP_741019.3, NP_001022041.2
Others
UniRef100: UniRef100_P23678
UniRef90: UniRef90_P23678
UniRef50: UniRef50_P23678
UniGene: Cel.5126

全选

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研究热度

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